Scudder Christopher J, Mirczuk Samantha M, Richardson Karen M, Crossley Victoria J, Regan Jacob T C, Gostelow Ruth, Forcada Yaiza, Hazuchova Katarina, Harrington Norelene, McGonnell Imelda M, Church David B, Kenny Patrick J, Korbonits Márta, Fowkes Robert C, Niessen Stijn J M
Diabetic Remission Clinic, Department of Clinical Science and Services, Royal Veterinary College, North Mymms, United Kingdom.
Endocrine Signaling Group, Department of Comparative Biomedical Sciences, Royal Veterinary College, London, United Kingdom.
J Endocr Soc. 2018 Oct 16;3(1):181-200. doi: 10.1210/js.2018-00226. eCollection 2019 Jan 1.
The prevalence of GH-secreting pituitary tumors in domestic cats () is 10-fold greater than in humans. The predominant inhibitory receptors of GH-secreting pituitary tumors are somatostatin receptors (SSTRs) and D dopamine receptor (DRD2). The expression of these receptors is associated with the response to somatostatin analog and dopamine agonist treatment in human patients with acromegaly. The aim of this study was to describe pathological features of pituitaries from domestic cats with acromegaly, pituitary receptor expression, and investigate correlates with clinical data, including pituitary volume, time since diagnosis of diabetes, insulin requirement, and serum IGF1 concentration. Loss of reticulin structure was identified in 15 of 21 pituitaries, of which 10 of 15 exhibited acinar hyperplasia. , , , and mRNA were identified in the feline pituitary whereas and were not. Expression of , , and was greater in acromegalic cats compared with controls. A negative correlation was identified between mRNA expression and pituitary volume. The loss of DRD2 expression should be investigated as a mechanism allowing the development of larger pituitary tumors.
家猫中分泌生长激素的垂体肿瘤患病率比人类高10倍。分泌生长激素的垂体肿瘤的主要抑制性受体是生长抑素受体（SSTRs）和D2多巴胺受体（DRD2）。这些受体的表达与肢端肥大症人类患者对生长抑素类似物和多巴胺激动剂治疗的反应相关。本研究的目的是描述患有肢端肥大症的家猫垂体的病理特征、垂体受体表达，并研究与临床数据的相关性，包括垂体体积、糖尿病诊断后的时间、胰岛素需求量和血清IGF1浓度。在21个垂体中的15个中发现网状纤维结构丧失，其中15个中的10个表现为腺泡增生。在猫垂体中鉴定出、、和mRNA，而未鉴定出和。与对照组相比，肢端肥大症猫中、和的表达更高。在mRNA表达与垂体体积之间发现负相关。DRD2表达的丧失应作为允许更大垂体肿瘤发展的一种机制进行研究。
