Ozoux J P, De Calan L, Rivallain B, Gandet O, Perrier M, Brizon J
Service de Chirurgie viscérale et endocrinienne, CHU Bretonneau, Tours.
J Chir (Paris). 1988 Jun-Jul;125(6-7):408-12.
A homogeneous series of 88 patients with a history of surgery for Basedow's disease was studied retrospectively to evaluate long term recurrences. A total of 88 cases were reviewed after a follow up of a median of 50 months (range 1 to 13 years), and hormone assays were carried out in 74 cases. Surgical complications were minor: no mortality, no definitive hypoparathyroidism, 45% unilateral recurrent nerve palsies and 14.3% definitive hypothyroidism occurring during the first year. Fifteen patients had one or several recurrences of hyperthyroidism. The actuarial recurrence rate at 5 years was 17%, the risk increasing progressively up to the sixth year. The type of operation was the only predictive factor of recurrence surveillance of these patients should be prolonged and involve regular hormone assays, since 6 of the 15 recurrences were poorly symptomatic.
对88例有格雷夫斯病手术史的患者进行了回顾性研究,以评估长期复发情况。在中位随访50个月(范围1至13年)后,共对88例病例进行了复查,并对74例进行了激素检测。手术并发症轻微:无死亡病例,无永久性甲状旁腺功能减退,第一年有45%的单侧喉返神经麻痹和14.3%的永久性甲状腺功能减退。15例患者有一次或多次甲亢复发。5年时的精算复发率为17%,风险逐年增加直至第6年。手术方式是复发的唯一预测因素。这些患者的复发监测应延长,并包括定期激素检测,因为15例复发中有6例症状不明显。