Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai 200032, PR China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, PR China.
Future Oncol. 2019 Feb;15(4):391-400. doi: 10.2217/fon-2018-0145. Epub 2019 Jan 8.
To examine the stage changes and survival differences among triple-negative breast cancer (TNBC) patients based on the prognostic staging system.
We used the SEER database to identify eligible patients with TNBC diagnosed between 2010 and 2014. Kaplan-Meier curves were drawn for comparison. The primary end point was breast cancer-specific survival.
The median follow-up time was 26 months for 19,608 patients. The stages of all TNBC patients increased or remained unchanged during rearrangement from anatomic staging to prognostic staging. Stage IIA, IIIA and IIIC comprised the majority of patients. Several patients did not have prognostic staging. Stage IIIC incorporated six substages that contributed to high heterogeneity. Overall, the Kaplan-Meier curves still showed the favorable differentiation among stages and substages, with the exception of stage IIB and substage IIIA (T2N0, grade 2-3) patients.
The prognostic information for breast cancer patients provided by the novel prognostic staging system may be less accurate for TNBC patients in our independent analysis. Moreover, stage IIB and substage IIIA (T2N0, grade 2-3) should possibly undergo further evaluation.
基于预后分期系统，研究三阴性乳腺癌（TNBC）患者的分期变化和生存差异。
我们使用 SEER 数据库，确定了 2010 年至 2014 年间诊断为 TNBC 的合格患者。绘制 Kaplan-Meier 曲线进行比较。主要终点是乳腺癌特异性生存。
19608 例患者的中位随访时间为 26 个月。所有 TNBC 患者的分期在从解剖分期到预后分期的重新排列过程中增加或保持不变。IIA、IIIA 和 IIIC 期占大多数患者。部分患者没有进行预后分期。IIIC 期包含六个亚期，导致高度异质性。总体而言，除了 IIB 期和 IIIA 亚期（T2N0、G2-3）患者外，Kaplan-Meier 曲线仍显示出各分期和亚期之间的良好分化。
在我们的独立分析中，新型预后分期系统为乳腺癌患者提供的预后信息可能对 TNBC 患者不够准确。此外，IIB 期和亚期 IIIA（T2N0、G2-3）可能需要进一步评估。
