Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou, China; Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, China.
J Surg Res. 2020 Mar;247:211-219. doi: 10.1016/j.jss.2019.09.072. Epub 2019 Nov 6.
The eighth edition of the American Cancer Joint Committee on Cancer (AJCC) staging system for breast cancer put forward the prognostic stage groups for the first time based on the traditional anatomic tumor-node-metastasis staging system. Our study intends to validate the predictive significance of the eighth edition staging system in triple-negative breast cancer (TNBC) patients.
We collected and accessed 26,589 eligible cases of TNBC from the Surveillance, Epidemiology, and End Results database (2010-2015) and reclassified the patient cohort according to the eighth edition of the AJCC staging system into anatomic and prognostic stages.
The results showed that more than half of the patients upstaged in the prognostic stage when compared with the anatomic stage. By comparing with the anatomic stage, the prognostic stage had a higher likelihood ratio and linear trend χ values. The prognostic stage group also had higher Akaike information criterion and Bayesian information criterion values than the anatomic stage group.
The prognostic staging system in TNBC patients performs more optimistic prognostic stratification and predictability than the anatomic staging system. Moreover, the latest AJCC staging system has a milestone importance to the history of breast cancer staging system.
第八版美国癌症联合委员会癌症分期系统（AJCC）首次提出了基于传统解剖学肿瘤-淋巴结-转移分期系统的预后分期组。本研究旨在验证第八版分期系统在三阴性乳腺癌（TNBC）患者中的预测意义。
我们从监测、流行病学和最终结果数据库（2010-2015 年）中收集并获取了 26589 例符合条件的 TNBC 患者，并根据第八版 AJCC 分期系统将患者队列重新分类为解剖学和预后分期。
结果显示，与解剖学分期相比，预后分期中有超过一半的患者分期升高。与解剖学分期相比，预后分期具有更高的似然比和线性趋势 χ 值。预后分期组的 Akaike 信息准则和贝叶斯信息准则值也高于解剖学分期组。
TNBC 患者的预后分期系统比解剖学分期系统具有更乐观的预后分层和预测能力。此外，最新的 AJCC 分期系统对乳腺癌分期系统的历史具有里程碑意义。
