1 Public Health, School of Medicine and Menzies Health Institute Queensland, Griffith University, Southport, Australia.
2 Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Metab Syndr Relat Disord. 2019 Mar;17(2):120-127. doi: 10.1089/met.2018.0026. Epub 2019 Jan 8.
The prevalence of metabolic syndrome (MetS) and its components have been increasing globally; therefore, there is a need for better understanding of MetS components and their risk factors, as well as their development and changes over time. This study was designed to identify the determinants of the changes in the components of MetS in a cohort of Iranian adults from 2001 to 2013.
A total of 6504 adults, ≥35 years of age, were recruited from central Iran in 2001and were followed up in an ongoing longitudinal population-based study for 12 years. Of the total, 3356 subjects were followed between 2001 and 2007 and 1385 subjects were followed between 2001 and 2013. MetS components and its risk factors were measured by standard methods in 2001, 2007, and 2013. Mean changes in the MetS components from 2001 to 2013 were assessed using the Generalized Estimating Equations test with three time points. Multivariate linear regression model was applied to examine the association between socioeconomic and behavioral characteristics and changes in MetS components. Furthermore, multivariate logistic regression analysis was carried out to examine various factors associated with the development of abnormality of MetS components.
Examining the biochemical and anthropometric characteristics of individuals from 2001 to 2013 revealed a significant increase in systolic and diastolic blood pressure, fasting blood sugar, waist circumference, and body mass index, and a significant decrease in total cholesterol, triglyceride, and physical activity levels. Results also indicated that age, gender, marital status, education levels, and area of residence were significantly associated with the changes in MetS components.
This study concluded that baseline sociodemographic characteristics are important in determining changes of MetS components.
代谢综合征（MetS）及其成分的患病率在全球范围内呈上升趋势；因此，需要更好地了解 MetS 成分及其危险因素，以及它们随时间的发展和变化。本研究旨在确定伊朗成年人队列中 MetS 成分变化的决定因素，该队列从 2001 年到 2013 年进行了随访。
2001 年，从伊朗中部招募了 6504 名年龄在 35 岁以上的成年人，并在一项持续的基于人群的纵向研究中进行了 12 年的随访。其中，3356 名受试者在 2001 年至 2007 年期间进行了随访，1385 名受试者在 2001 年至 2013 年期间进行了随访。2001 年、2007 年和 2013 年采用标准方法测量 MetS 成分及其危险因素。采用广义估计方程检验评估 2001 年至 2013 年期间 MetS 成分的平均变化。采用多元线性回归模型分析社会经济和行为特征与 MetS 成分变化之间的关系。此外，采用多元逻辑回归分析方法分析与 MetS 成分异常发展相关的各种因素。
检查 2001 年至 2013 年个体的生化和人体测量特征发现，收缩压和舒张压、空腹血糖、腰围和体重指数显著增加，总胆固醇、甘油三酯和体力活动水平显著降低。结果还表明，年龄、性别、婚姻状况、教育水平和居住区域与 MetS 成分的变化显著相关。
本研究得出结论，基线社会人口统计学特征是决定 MetS 成分变化的重要因素。
