Wargovich M J
Department of Medical Oncology, M.D. Anderson Hospital and Tumor Institute, Houston, Texas 77030.
J Am Coll Nutr. 1988 Aug;7(4):295-300. doi: 10.1080/07315724.1988.10720246.
Calcium has been hypothesized as being a regulator of cell proliferation in the colon. Epidemiologic studies suggest that ingestion of higher levels of dietary calcium are related to a decreased risk for colon cancer. Short term studies in vitro and in vivo of the proliferative behavior of human and animal colon mucosa verify that calcium does modulate proliferative response. Preliminary clinical studies suggest that the hyperproliferative mucosa of patients at high risk for colon cancer, based on proliferation analysis of biopsied mucosa, became decidedly less proliferative when the subjects were given oral calcium. Our studies address the molecular mechanisms by which calcium controls mucosal proliferation and the ways in which tumor cells circumvent this regulation.
钙被假定为结肠细胞增殖的调节因子。流行病学研究表明，摄入较高水平的膳食钙与结肠癌风险降低有关。对人和动物结肠黏膜增殖行为的短期体外和体内研究证实，钙确实能调节增殖反应。初步临床研究表明，基于活检黏膜的增殖分析，结肠癌高危患者的高增殖性黏膜在受试者口服钙后，增殖明显减少。我们的研究探讨了钙控制黏膜增殖的分子机制以及肿瘤细胞规避这种调节的方式。
