来自索马里菊蒿的抗原生动物吉马烷型倍半萜内酯
Antiprotozoal Germacranolide Sesquiterpene Lactones from Tanacetum sonbolii.
作者信息
Mofidi Tabatabaei Sahar, Nejad Ebrahimi Samad, Salehi Peyman, Sonboli Ali, Tabefam Marzieh, Kaiser Marcel, Hamburger Matthias, Moridi Farimani Mahdi
机构信息
Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran.
Department of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran.
出版信息
Planta Med. 2019 Mar;85(5):424-430. doi: 10.1055/a-0824-1294. Epub 2019 Jan 8.
A phytochemical investigation of extracts from flowers and aerial parts of afforded 7 new germacranolide sesquiterpene lactones. The structures were established by a combination of 1- and 2-dimensional nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, and electronic circular dichroism. The antiprotozoal activity of the compounds against and cytotoxicity against rat myoblast (L6) cells were determined. Compounds 4: and 5: showed IC values of 5.1 and 10.2 µM and selectivity indices of 3.9 and 4.0, respectively.
对[植物名称]花和地上部分提取物进行的植物化学研究得到了7种新的吉马烷型倍半萜内酯。通过一维和二维核磁共振光谱、高分辨率质谱和电子圆二色性相结合的方法确定了其结构。测定了这些化合物对[原虫名称]的抗原虫活性以及对大鼠成肌细胞（L6）的细胞毒性。化合物4和5的半数抑制浓度（IC）值分别为5.1和10.2 μM，选择性指数分别为3.9和4.0。
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