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[胸外科体外膜肺氧合:麻醉医生的视角]

[Extracorporeal Membrane Oxygenation in Thoracic Surgery: the Anesthesiologist's Perspective].

作者信息

Rehers Stephanie, Beiderlinden Martin, Ziegeler Stephan

机构信息

Anästhesie, operative Intensivmedizin, Schmerztherapie und Notfallmedizin, Klinikum Ibbenbüren, Deutschland.

Anästhesiologie, Marienhospital Osnabrück, Deutschland.

出版信息

Zentralbl Chir. 2019 Feb;144(1):86-92. doi: 10.1055/a-0774-8151. Epub 2019 Jan 8.

DOI:10.1055/a-0774-8151
PMID:30620971
Abstract

"Enhanced Recovery after Surgery" programs have been developed for thoracic surgery over the last couple of years. Besides minimally invasive surgical techniques, there are a number of anaesthesiological aspects like the choice of short acting anaesthetics, the use of regional analgesia, a balanced intraoperative fluid therapy, the avoidance of postoperative nausea and vomiting and, most importantly, protective ventilation, that need to be considered. In patients undergoing thoracic surgery procedures with preexisting severe limitations in pulmonary function, protective ventilation under the conditions of one lung ventilation often leads to severe dysfunction of pulmonary gas exchange. In this situation, establishing veno-venous membrane oxygenation (vvECMO) is a sufficient and safe method to facilitate perioperative treatment of these patients. Postoperatively, patients benefit from the continuation of the conscious vvECMO by augmentation of necessary therapeutic procedures such as physical and respiratory therapy or early mobilisation as well as healing of air leakage of the operated lung. To avoid bleeding complications, ECMO can be operated without anticoagulation intraoperatively with heparin-coating of the tube system. Postoperatively, heparin, argatroban or bivalirudin are options for anticoagulation. New techniques like minimally-invasive thoracic surgery under regional anaesthesia and sedation can potentially be developed further using vvECMO support in the future.

摘要

在过去几年中,已经为胸外科手术开发了“术后加速康复”计划。除了微创手术技术外,还有许多麻醉学方面的问题需要考虑,比如短效麻醉剂的选择、区域镇痛的使用、术中液体平衡治疗、避免术后恶心和呕吐,以及最重要的保护性通气。在肺功能预先存在严重受限的胸外科手术患者中,单肺通气条件下的保护性通气常常导致严重的肺气体交换功能障碍。在这种情况下,建立静脉-静脉膜肺氧合(vvECMO)是促进这些患者围手术期治疗的一种充分且安全的方法。术后,患者通过加强必要的治疗程序(如物理治疗和呼吸治疗或早期活动)以及手术肺漏气的愈合,从持续的清醒vvECMO中获益。为避免出血并发症,术中可在管路系统肝素涂层的情况下不进行抗凝而运行ECMO。术后,肝素、阿加曲班或比伐卢定是抗凝的选择。未来,在vvECMO支持下,像区域麻醉和镇静下的微创胸外科手术等新技术可能会得到进一步发展。

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[Extracorporeal Membrane Oxygenation in Thoracic Surgery: the Anesthesiologist's Perspective].[胸外科体外膜肺氧合:麻醉医生的视角]
Zentralbl Chir. 2019 Feb;144(1):86-92. doi: 10.1055/a-0774-8151. Epub 2019 Jan 8.
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Membrane oxygenator longevity was higher in argatroban-treated patients undergoing vvECMO.在接受 vvECMO 的患者中,使用阿加曲班治疗的患者的膜式氧合器寿命更长。
Eur J Clin Invest. 2023 Jun;53(6):e13963. doi: 10.1111/eci.13963. Epub 2023 Feb 14.

引用本文的文献

1
Superiority of bivalirudin over heparin anticoagulation therapy for extracorporeal membrane oxygenation? Too early to draw conclusions.比伐卢定在体外膜肺氧合抗凝治疗中优于肝素?现在下结论还为时过早。
Heliyon. 2023 Feb 6;9(2):e13530. doi: 10.1016/j.heliyon.2023.e13530. eCollection 2023 Feb.
2
Outcomes from the Use of Perioperative Extracorporeal Membrane Oxygenation in Patients Undergoing Thoracic Surgery: An 8-Year Single-Center Experience.体外膜肺氧合在胸外科手术患者中的应用效果:8 年单中心经验。
Med Sci Monit. 2021 Nov 2;27:e931842. doi: 10.12659/MSM.931842.
3
Anesthesiological considerations in emphysema surgery.
肺气肿手术的麻醉学考量
Ann Transl Med. 2020 Nov;8(21):1470. doi: 10.21037/atm-2019-le-06.