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食用含有 CNCM I-2494 的发酵乳产品对有轻微消化症状的女性的快速反应:与膳食纤维摄入或体力活动无关。

Consumption of a Fermented Milk Product Containing CNCM I-2494 in Women Complaining of Minor Digestive Symptoms: Rapid Response Which Is Independent of Dietary Fibre Intake or Physical Activity.

机构信息

Sorbonne Université, INSERM, Laboratoire des Biomolécules (LBM), 27 rue de Chaligny, 75012 Paris, France.

APHP, Pôle Digestif, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France.

出版信息

Nutrients. 2019 Jan 4;11(1):92. doi: 10.3390/nu11010092.


DOI:10.3390/nu11010092
PMID:30621211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6356475/
Abstract

Minor digestive symptoms are common and dietary approaches such as probiotic administration or fibre and fermentable carbohydrate intake adjustments are often recommended. A Fermented Milk Product (FMP) containing subsp. CNCM I-2494 and lactic acid bacteria has been shown to improve digestive symptoms after 4 weeks of consumption, but the speed of onset of this effect and its dependence on fibre intake or physical activity is unknown. To answer these questions, data from two previously published trials on FMP for minor digestive symptoms were combined. In total, 538 participants provided weekly assessments of bloating, abdominal pain/discomfort, flatulence, borborygmi/rumbling stomach from which a composite score was calculated. At baseline in one study ( = 336), dietary fibre consumption was recorded and physical activity classified as high, moderate or low. The speed of the FMP's effect was assessed by a repeated measure analysis of variance measuring the change from baseline for the composite score of digestive symptoms. FMP consumption resulted in a significant decrease in the composite score of symptoms after only 2 weeks in both studies and the pooled data at week 1 (-0.35 [-0.69, 0.00]; = 0.05), week 2 (-0.66 [-1.04, -0.27]; < 0.001), week 3 (-0.49 [-0.89, -0.10]; = 0.01) and week 4 (-0.46 [-0.88, -0.04]; = 0.03). The interactions fibre intake-by-product group, physical activity-by-product group and time-by-product group were not statistically significant. FMP consumption leads to a rapid improvement in symptoms which is likely to encourage adherence to this dietary intervention. This effect is independent of dietary fibre and physical activity.

摘要

轻微的消化症状很常见,通常建议采用益生菌给药或纤维和可发酵碳水化合物摄入调整等饮食方法。含有 subsp. CNCM I-2494 和乳酸菌的发酵乳产品(FMP)已被证明可在 4 周的食用后改善消化症状,但这种效果的出现速度及其对纤维摄入或体力活动的依赖程度尚不清楚。为了回答这些问题,对先前发表的两项关于 FMP 治疗轻微消化症状的试验数据进行了合并。共有 538 名参与者每周评估腹胀、腹痛/不适、气胀、肠鸣/胃部咕噜声,并计算出综合评分。在一项研究的基线时(n = 336),记录了膳食纤维的摄入量,并将体力活动分为高、中、低。通过重复测量方差分析来评估 FMP 作用的速度,该分析测量了从基线开始消化症状综合评分的变化。在两项研究和合并数据中,FMP 的消耗在仅 2 周后就显著降低了症状的综合评分,在第 1 周(-0.35 [-0.69, 0.00]; = 0.05)、第 2 周(-0.66 [-1.04, -0.27];< 0.001)、第 3 周(-0.49 [-0.89, -0.10]; = 0.01)和第 4 周(-0.46 [-0.88, -0.04]; = 0.03)。纤维摄入量-产品组、体力活动-产品组和时间-产品组之间的相互作用不具有统计学意义。FMP 的消耗可迅速改善症状,这可能会鼓励人们坚持这种饮食干预。这种效果与膳食纤维和体力活动无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b6b/6356475/d6355ce88540/nutrients-11-00092-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b6b/6356475/d6355ce88540/nutrients-11-00092-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b6b/6356475/d6355ce88540/nutrients-11-00092-g001.jpg

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[4]
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[5]
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[6]
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本文引用的文献

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Minor digestive symptoms and their impact in the general population: a cluster analysis approach.

Therap Adv Gastroenterol. 2018-4-22

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Aliment Pharmacol Ther. 2018-2-20

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Am J Gastroenterol. 2017-1

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