光遗传学研究酒精使用障碍的神经机制。
Optogenetic investigation of neural mechanisms for alcohol-use disorder.
机构信息
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Pharmacology, University of Washington, Seattle, WA, United States.
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Key Laboratory of Functional Proteomics of Guangdong Province, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
出版信息
Alcohol. 2019 Feb;74:29-38. doi: 10.1016/j.alcohol.2018.05.005. Epub 2018 Jun 19.
Optogenetic techniques have been widely used in the study of neuropsychiatric diseases such as anxiety, depression, and drug addiction. Cell-type specific targeting of optogenetic tools to neurons has contributed to a tremendous understanding of the function of neural circuits for future treatment of neuropsychiatric disorders. Though optogenetics has been widely used in many research areas, the use of optogenetic tools to uncover and elucidate neural circuit mechanisms of alcohol's actions in the brain are still developing. Here in this review article, we will provide a basic introduction to optogenetics and discuss how these optogenetic experimental approaches can be used in alcohol studies to reveal neural circuit mechanisms of alcohol's actions in regions implicated in the development of alcohol addiction.
光遗传学技术已广泛应用于焦虑、抑郁和药物成瘾等神经精神疾病的研究。光遗传学工具对神经元的细胞类型特异性靶向作用有助于极大地了解神经回路的功能，为未来治疗神经精神疾病提供了帮助。尽管光遗传学已广泛应用于许多研究领域，但利用光遗传学工具来揭示和阐明酒精在大脑中的作用的神经回路机制仍在不断发展。在这篇综述文章中，我们将对光遗传学进行基本介绍，并讨论如何将这些光遗传学实验方法应用于酒精研究，以揭示与酒精成瘾发展相关区域中酒精作用的神经回路机制。
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