光遗传学策略解析奖赏和成瘾的神经回路。
Optogenetic strategies to dissect the neural circuits that underlie reward and addiction.
机构信息
Curriculum in Neurobiology, University of North Carolina at Chapel Hill, 27599, USA.
出版信息
Cold Spring Harb Perspect Med. 2012 Nov 1;2(11):a011924. doi: 10.1101/cshperspect.a011924.
Abstract
Optogenetic strategies for perturbation of neural circuit function have begun to revolutionize systems neuroscience. Whereas optogenetics has proven to be a powerful approach for studying neural systems, the tools to conduct these experiments are still continuously evolving. Here we briefly summarize available hardware and reagents that can be used for studying behaviors related to reward and addiction. In addition, we discuss recent studies in which these strategies have been applied to study neural circuit function in brain slices as well as awake and behaving animals. Collectively, this work serves as a brief introduction to optogenetic techniques and highlights how these tools can be applied to elucidate the neural circuits that underlie reward processing and addiction.
摘要
光遗传学策略在神经回路功能的干扰方面的应用已经开始给系统神经科学带来革命性的变化。虽然光遗传学已被证明是研究神经系统的有力方法，但进行这些实验的工具仍在不断发展。在这里，我们简要总结了可用于研究与奖励和成瘾相关行为的现有硬件和试剂。此外，我们还讨论了最近的一些研究，这些研究应用了这些策略来研究脑切片以及清醒和行为动物中的神经回路功能。总的来说，这项工作是对光遗传学技术的简要介绍，并强调了这些工具如何应用于阐明奖励处理和成瘾的神经回路。
相似文献
1
Optogenetic strategies to dissect the neural circuits that underlie reward and addiction.
Cold Spring Harb Perspect Med. 2012 Nov 1;2(11):a011924. doi: 10.1101/cshperspect.a011924.
2
Optogenetic modulation of neural circuits that underlie reward seeking.
Biol Psychiatry. 2012 Jun 15;71(12):1061-7. doi: 10.1016/j.biopsych.2011.11.010. Epub 2011 Dec 22.
3
Activation of Pedunculopontine Glutamate Neurons Is Reinforcing.
J Neurosci. 2017 Jan 4;37(1):38-46. doi: 10.1523/JNEUROSCI.3082-16.2016.
4
Neural integration of reward, arousal, and feeding: recruitment of VTA, lateral hypothalamus, and ventral striatal neurons.
IUBMB Life. 2011 Oct;63(10):824-30. doi: 10.1002/iub.539. Epub 2011 Sep 7.
5
Optogenetic investigation of neural mechanisms for alcohol-use disorder.
Alcohol. 2019 Feb;74:29-38. doi: 10.1016/j.alcohol.2018.05.005. Epub 2018 Jun 19.
6
Contributions of dopaminergic and non-dopaminergic neurons to VTA-stimulation induced neurovascular responses in brain reward circuits.
Neuroimage. 2018 Aug 15;177:88-97. doi: 10.1016/j.neuroimage.2018.04.059. Epub 2018 Apr 30.
7
Developments from Bulk Optogenetics to Single-Cell Strategies to Dissect the Neural Circuits that Underlie Aberrant Motivational States.
Cold Spring Harb Perspect Med. 2022 Mar 1;12(3):a039792. doi: 10.1101/cshperspect.a039792.
8
Viral vector strategies for investigating midbrain dopamine circuits underlying motivated behaviors.
Pharmacol Biochem Behav. 2018 Nov;174:23-32. doi: 10.1016/j.pbb.2017.02.006. Epub 2017 Feb 28.
9
Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula-Tegmental Circuitry and Constrain Reward Seeking.
Biol Psychiatry. 2018 Jun 15;83(12):1012-1023. doi: 10.1016/j.biopsych.2018.01.003. Epub 2018 Jan 12.
10
Neural circuits provide insights into reward and aversion.
Front Neural Circuits. 2022 Oct 28;16:1002485. doi: 10.3389/fncir.2022.1002485. eCollection 2022.
引用本文的文献
1
Reorganization of lateral habenula neuronal connectivity underlies pain-related impairment in spatial memory encoding.
Pain. 2024 Dec 11;166(7):1532-1548. doi: 10.1097/j.pain.0000000000003493.
2
Optical Intracranial Self-Stimulation (oICSS): A New Behavioral Model for Studying Drug Reward and Aversion in Rodents.
Int J Mol Sci. 2024 Mar 19;25(6):3455. doi: 10.3390/ijms25063455.
3
Optogenetic Activation of β-Endorphin Terminals in the Medial Preoptic Nucleus Regulates Female Sexual Receptivity.
eNeuro. 2020 Jan 24;7(1). doi: 10.1523/ENEURO.0315-19.2019. Print 2020 Jan/Feb.
4
Nonhuman animal models of substance use disorders: Translational value and utility to basic science.
Drug Alcohol Depend. 2020 Jan 1;206:107733. doi: 10.1016/j.drugalcdep.2019.107733. Epub 2019 Nov 21.
5
From Synapse to Function: A Perspective on the Role of Neuroproteomics in Elucidating Mechanisms of Drug Addiction.
Proteomes. 2018 Dec 9;6(4):50. doi: 10.3390/proteomes6040050.
6
Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms.
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Dec 20;87(Pt A):33-47. doi: 10.1016/j.pnpbp.2018.01.002. Epub 2018 Jan 3.
7
Dopamine System Dysregulation in Major Depressive Disorders.
Int J Neuropsychopharmacol. 2017 Dec 1;20(12):1036-1046. doi: 10.1093/ijnp/pyx056.
8
Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior.
Elife. 2017 Sep 5;6:e30697. doi: 10.7554/eLife.30697.
9
Role of a Lateral Orbital Frontal Cortex-Basolateral Amygdala Circuit in Cue-Induced Cocaine-Seeking Behavior.
Neuropsychopharmacology. 2017 Feb;42(3):727-735. doi: 10.1038/npp.2016.157. Epub 2016 Aug 18.
10
Ventromedial hypothalamic neurons control a defensive emotion state.
Elife. 2015 Mar 6;4:e06633. doi: 10.7554/eLife.06633.
本文引用的文献
1
Neuron-type-specific signals for reward and punishment in the ventral tegmental area.
Nature. 2012 Jan 18;482(7383):85-8. doi: 10.1038/nature10754.
2
GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons.
Nat Neurosci. 2011 Dec 11;15(1):123-30. doi: 10.1038/nn.2984.
3
Construction of implantable optical fibers for long-term optogenetic manipulation of neural circuits.
Nat Protoc. 2011 Dec 8;7(1):12-23. doi: 10.1038/nprot.2011.413.
4
Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement.
Neuron. 2011 Dec 8;72(5):721-33. doi: 10.1016/j.neuron.2011.10.028.
5
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function.
Nat Methods. 2011 Sep;8(9):745-52. doi: 10.1038/nmeth.1668.
6
Neocortical excitation/inhibition balance in information processing and social dysfunction.
Nature. 2011 Jul 27;477(7363):171-8. doi: 10.1038/nature10360.
7
Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior.
J Neurosci. 2011 Jul 27;31(30):10829-35. doi: 10.1523/JNEUROSCI.2246-11.2011.
8
Optogenetics in neural systems.
Neuron. 2011 Jul 14;71(1):9-34. doi: 10.1016/j.neuron.2011.06.004.
9
Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking.
Nature. 2011 Jun 29;475(7356):377-80. doi: 10.1038/nature10194.
10
The development and application of optogenetics.
Annu Rev Neurosci. 2011;34:389-412. doi: 10.1146/annurev-neuro-061010-113817.
Zotero 插件