Martsevich S Iu, Metelitsa V I
Kardiologiia. 1988 Jul;28(7):68-70.
The markedness and duration of antianginal effects of 2 mg molsidomine and 10 mg isosorbide dinitrate were compared by means of repeated treadmill tests in 37 coronary patients with stable angina of effort. Peak magnitude of the effect was similar with both drugs, while the duration of the effect of isosorbide dinitrate (4.0 +/- 0.3 hrs) was significantly greater than that of molsidomine (3.4 +/- 0.3 hrs). Molsidomine reached its peak effect significantly earlier, as compared to isosorbide dinitrate. There was a significant correlation between the effectiveness of molsidomine and isosorbide dinitrate in the same patients.
通过对37例稳定型劳力性心绞痛冠心病患者进行反复的平板运动试验，比较了2毫克吗多明和10毫克硝酸异山梨酯抗心绞痛作用的显著程度和持续时间。两种药物的最大效应峰值相似，但硝酸异山梨酯的效应持续时间（4.0±0.3小时）显著长于吗多明（3.4±0.3小时）。与硝酸异山梨酯相比，吗多明达到峰值效应的时间明显更早。在同一患者中，吗多明和硝酸异山梨酯的有效性之间存在显著相关性。
