Division of Gastroenterology and Hepatology, Department of Internal Medicine, Thomas Jefferson University, Philadelphia, PA 19107, United States.
World J Gastroenterol. 2018 Dec 28;24(48):5433-5438. doi: 10.3748/wjg.v24.i48.5433.
Checkpoint inhibitors are increasingly being used in clinical practice. They can cause various gastrointestinal, hepatic and pancreatic side effects. As these side effects can be serious, appropriate management is essential. The different checkpoint inhibitors with their mechanisms of action and indications, as well as evaluation and management of gastrointestinal, hepatic and pancreatic side effects, are discussed in this article.
检查点抑制剂在临床实践中越来越多地被使用。它们会引起各种胃肠道、肝脏和胰腺的副作用。由于这些副作用可能很严重，因此适当的管理是必不可少的。本文讨论了不同的检查点抑制剂及其作用机制和适应证，以及胃肠道、肝脏和胰腺副作用的评估和管理。
