结直肠癌中CD34免疫标记血管与CD34 mRNA表达的相关性
Correlations between CD34 Immunolabelled Blood Vessels and CD34 mRNA Expression in Colorectal Cancer.
作者信息
Toma S C, Uscatu C D, Ungureanu B S, Mirea C S, Dumitrescu T, Georgescu E F, Schenker M, Surlin V, Georgescu I
机构信息
Department of Surgery, University of Medicine and Pharmacy of Craiova.
Emergency County Hospital, Pitesti.
出版信息
Curr Health Sci J. 2018 Jan-Mar;44(1):60-63. doi: 10.12865/CHSJ.44.01.10. Epub 2018 Mar 18.
PURPOSE
This study aims to determine the correlation between microvessel density of CD34 immunolabelled blood vessels and CD34 mRNA gene expression in colorectal cancer tissue.
MATERIAL/METHODS: Standard immunohistochemistry and gene expression was perform on samples collected from 76 patients with colorectal cancer in order to determinate the number of CD34 immunolabelled blood vessels and the relative quantity of CD34 mRNA.
RESULTS
For the study group, the mean CD34 immunolabelled microvascular density (MVD) was of 307/mm, and the mean CD34 gene expression value for colon cancer was 2.303. The low p value (<0.001) of the Spearman correlation test showed a significant direct correlation between CD34 MVD and CD34 gene expression for the entire study group.
CONCLUSIONS
CD34 gene`s expression can be looked at as a prognostic factor in colorectal cancer.
目的
本研究旨在确定结直肠癌组织中CD34免疫标记血管的微血管密度与CD34 mRNA基因表达之间的相关性。
材料/方法：对76例结直肠癌患者采集的样本进行标准免疫组织化学和基因表达检测，以确定CD34免疫标记血管的数量和CD34 mRNA的相对量。
结果
研究组中，CD34免疫标记微血管密度（MVD）的平均值为307/mm，结肠癌的CD34基因表达平均值为2.303。Spearman相关性检验的低p值（<0.001）表明，整个研究组中CD34 MVD与CD34基因表达之间存在显著的正相关。
结论
CD34基因的表达可被视为结直肠癌的一个预后因素。
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