肌肉功能和年龄与杜氏肌营养不良症的骨密度丢失有关。
Muscle function and age are associated with loss of bone mineral density in Duchenne muscular dystrophy.
机构信息
Laboratorio de Nutrición Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI-IMSS, Av. Cuauhtémoc No. 330, Col. Doctores, Delegación, Cuauhtémoc, 06725, Ciudad de México, México.
Laboratorio de Biomembranas, Departamento de Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico.
出版信息
Muscle Nerve. 2019 Apr;59(4):417-421. doi: 10.1002/mus.26416. Epub 2019 Jan 22.
INTRODUCTION
Patients with Duchenne muscular dystrophy (DMD) demonstrate decreased bone mineral density (BD). It is not clear which factors exert the greatest impact on BD loss in these patients.
METHODS
In 63 patients with DMD, serum cytokines (interleukin [IL]-1, IL-6, and tumor necrosis factor-beta [TNF-β]), C-reactive protein (CRP), creatine kinase (CK), muscle function (by Vignos scale), body composition, and total BD (the latter 2 measured by dual-energy X-ray absorptiometry, or DEXA) were determined.
RESULTS
The main factors associated with BD loss were muscle function (34.0%; β = -0.139; P < 0.023) and age (36.7%; β = -0.151; P = 0.004). Cytokines, CRP, body fat mass, and CK did not contribute to BD loss.
DISCUSSION
Muscle function and age contribute to BD loss in DMD. We propose that a cut-off of at least 6 points for the Vignos scale and at least 10.5 years of age predict a Z-score of less than or equal to -2.0. Muscle Nerve 59:417-421, 2019.
简介
杜兴氏肌营养不良症（DMD）患者的骨矿物质密度（BD）降低。目前尚不清楚哪些因素对这些患者的 BD 丧失影响最大。
方法
对 63 例 DMD 患者的血清细胞因子（白细胞介素[IL]-1、IL-6 和肿瘤坏死因子-β[TNF-β]）、C 反应蛋白（CRP）、肌酸激酶（CK）、肌肉功能（通过 Vignos 量表）、身体成分和总 BD（后两者通过双能 X 线吸收法，或 DEXA 测量）进行了测定。
结果
与 BD 丧失相关的主要因素是肌肉功能（34.0%；β=-0.139；P<0.023）和年龄（36.7%；β=-0.151；P=0.004）。细胞因子、CRP、体脂肪量和 CK 对 BD 丧失没有贡献。
讨论
肌肉功能和年龄是导致 DMD 中 BD 丧失的原因。我们建议，Vignos 量表的评分至少为 6 分，年龄至少为 10.5 岁，可以预测 Z 评分小于或等于-2.0。肌肉神经 59:417-421,2019.
Zotero 插件