Takrouri M S, Toukan A, Badran I, Sbeih Z, Hunjul N
Faculty of Medicine, Jordan University of Science and Technology, Irbid.
Middle East J Anaesthesiol. 1988 Oct;9(6):529-36.
One hundred twenty patients undergoing elective endoscopies were studied. They were allocated into three groups and accordingly they received Diazepam, Flunitrazepam and Midazolam. The effect of these drugs on the task performance of the patient's memory, anxiety and sedation level were assessed using objective tests. Cardiovascular and respiratory parameters were also assessed. All observations were subjected to student's t-test and chi squared assessment. We concluded that there are no major differences between the three drugs in the dosage used. However, the Midazolam group showed faster recovery, more sedation, less pain on injection than the Diazepam group. As for the cardiovascular system, there was a tendency for hypotension and tachycardia in all groups. Patients in the Midazolam group had more amnesia as compared to the other groups.
对120例行择期内镜检查的患者进行了研究。他们被分为三组，并分别接受地西泮、氟硝西泮和咪达唑仑治疗。使用客观测试评估这些药物对患者记忆、焦虑和镇静水平任务表现的影响。还评估了心血管和呼吸参数。所有观察结果均进行了学生t检验和卡方评估。我们得出结论，在所使用的剂量下，这三种药物之间没有重大差异。然而，与地西泮组相比，咪达唑仑组恢复更快、镇静作用更强、注射时疼痛更少。至于心血管系统，所有组均有低血压和心动过速的倾向。与其他组相比，咪达唑仑组的患者失忆情况更多。
