Nimmo W S, Forrest J A, Heading R C, Finlayson N D, Prescott L F
Endoscopy. 1978 Aug;10(3):183-6. doi: 10.1055/s-0028-1098290.
Flunitrazepam or diazepam with atropine and a combination of phenoperidine, droperidol and cyclizine (neuroleptanalgesia) were compared as premedication in three groups of 25 patients undergoing routine upper gastrointestinal endoscopy. Drug doses were titrated carefully against response and all three regimes were found to be similar in terms of safety, patient co-operation, relaxation and speed of recovery. Neuroleptanalgesia however produced a statistically significant rise in endtidal pCO2 and systolic blood pressure. The benzodiazepines, and in particular flunitrazepam, produced a significantly greater amnesia for the procedure, patients given these drugs being more willing to undergo repeat endoscopy.
在三组25例接受常规上消化道内镜检查的患者中，比较了氟硝西泮或地西泮联合阿托品，以及哌替啶、氟哌利多和赛克利嗪的组合（神经安定镇痛）作为术前用药的效果。根据反应仔细调整药物剂量，发现所有三种方案在安全性、患者配合度、放松程度和恢复速度方面相似。然而，神经安定镇痛使呼气末二氧化碳分压和收缩压在统计学上显著升高。苯二氮䓬类药物，尤其是氟硝西泮，对该操作产生了显著更强的遗忘作用，使用这些药物的患者更愿意接受重复内镜检查。
