从越南海洋沉积物来源的真菌中分离得到与金锦香素有关的神经保护化合物。
Auroglaucin-related neuroprotective compounds from Vietnamese marine sediment-derived fungus .
机构信息
G.B. Elyakov Pacific Institute of bioorganic chemistry, Vladivostok, Russia.
Department of marine biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang, Vietnam.
出版信息
Nat Prod Res. 2020 Sep;34(18):2589-2594. doi: 10.1080/14786419.2018.1547293. Epub 2019 Jan 9.
Two new auroglaucin-derived compounds, niveoglaucins A () and B (), together with four known related compounds were isolated from extract of the marine sediment-derived strain of . The structures of these compounds were determined by 1D and 2D NMR spectroscopy and high resolution MS. The plausible biosynthetic pathway was proposed for new compounds and . The neuroprotective activity in 6-OHDA-induced Parkinson's disease cell model was shown for niveoglaucin A ().
从海洋沉积物来源的菌株中分离得到两种新型的金顶侧耳素衍生化合物，niveoglaucins A()和 B()，以及另外四种已知的相关化合物。通过 1D 和 2D NMR 光谱和高分辨率 MS 确定了这些化合物的结构。提出了新化合物和的可能生物合成途径。niveoglaucins A()在 6-OHDA 诱导的帕金森病细胞模型中显示出神经保护活性。
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