G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia.
Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, 650000 Nha Trang, Vietnam.
Molecules. 2019 Dec 23;25(1):61. doi: 10.3390/molecules25010061.
Seven known echinulin-related indolediketopiperazine alkaloids (-) were isolated from the Vietnamese sediment-derived fungus . Using chiral HPLC, the enantiomers of cryptoechinuline B () were isolated as individual compounds for the first time. (+)-Cryptoechinuline B () exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson's disease. (-)-Cryptoechinuline B () and neoechinulin C () protected the neuronal cells against paraquat-induced damage in a Parkinson's disease model. Neoechinulin B () exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin () showed activity in the 6-OHDA-induced model.
从越南沉积物来源的真菌中分离得到 7 种已知的棘白菌素相关吲哚二酮哌嗪生物碱（-）。利用手性 HPLC，首次将隐棘白菌素 B（()）的对映异构体分离为单个化合物。（+）-隐棘白菌素 B（()）在 6-OHDA、百草枯和鱼藤酮诱导的帕金森病体外模型中表现出神经保护活性。（-）-隐棘白菌素 B（()）和新棘白菌素 C（()）在帕金森病模型中保护神经元细胞免受百草枯诱导的损伤。新棘白菌素 B（()）在鱼藤酮诱导的模型中表现出细胞保护活性，而新棘白菌素（()）在 6-OHDA 诱导的模型中表现出活性。
