a Department of Obstetrics and Gynecology , Sivas Sarkisla Government Hospital , Sivas , Turkey.
b Department of Obstetrics and Gynecology , Health Sciences University, Kayseri Education and Research Hospital , Kayseri , Turkey.
Gynecol Endocrinol. 2019 Jun;35(6):535-538. doi: 10.1080/09513590.2018.1554038. Epub 2019 Jan 9.
Gestational diabetes mellitus (GDM), is the most common medical complications of pregnancy. This study aimed to clarify the effect of second-trimester vitamin D deficiency on the 75 g oral glucose tolerance test (OGTT) screening and insulin resistance. A total of 120 pregnant women with a singleton pregnancy at a gestational age of 26-28 weeks were analyzed. Participants were divided into two groups according to 25-hydroxyvitamin D levels; vitamin D deficiency, and control groups. For GDM scan, 75 g OGTT was preferred. GDM prevalence was 17.5% in vitamin D deficiency group and 13.75% in control group, there is no significant difference in GDM prevalence (p = 0.149). Fasting plasma glucose and 1-h plasma glucose levels were significantly higher in the vitamin D deficiency group than in the control group (p < .001 and p < .001, respectively). No significant differences were observed between 2-hour plasma glucose levels (p = .266). The HOMA-IR level was significantly higher in the vitamin D deficiency group than in the control group (p < .001). The findings of the present study suggested that vitamin D deficiency in the second trimester was inversely correlated with fasting and 1-h plasma glucose after 75 g glucose challenge test; also, low 25 OHD levels were associated with insulin resistance.
妊娠期糖尿病（GDM）是妊娠最常见的医学并发症。本研究旨在阐明孕中期维生素 D 缺乏对 75g 口服葡萄糖耐量试验（OGTT）筛查和胰岛素抵抗的影响。共分析了 120 名孕龄 26-28 周的单胎妊娠孕妇。根据 25-羟维生素 D 水平将参与者分为两组；维生素 D 缺乏组和对照组。对于 GDM 扫描，首选 75g OGTT。维生素 D 缺乏组的 GDM 患病率为 17.5%，对照组为 13.75%，GDM 患病率无显著差异（p=0.149）。维生素 D 缺乏组的空腹血糖和 1 小时血糖水平明显高于对照组（p<0.001 和 p<0.001）。2 小时血糖水平无显著差异（p=0.266）。维生素 D 缺乏组的 HOMA-IR 水平明显高于对照组（p<0.001）。本研究结果表明，孕中期维生素 D 缺乏与 75g 葡萄糖负荷试验后空腹和 1 小时血糖呈负相关；此外，25-OHD 水平低与胰岛素抵抗有关。
