Khorasani Zahra Mazloum, Bonakdaran Shokoufeh, Rafieie Hasan Pour
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Curr Diabetes Rev. 2019;15(5):414-419. doi: 10.2174/1573399814666181102100816.
Diabetes Mellitus is one of the most common medical disorders in pregnancy. The possibility of vitamin D deficiency as a pathogenesis for impaired glucose tolerance tests show a probable role of vitamin D in insulin secretion and reduction of insulin resistance. This study was assigned to evaluate relation between serum vitamin D level and insulin resistance in Gestational Diabetes Mellitus (GDM).
This cross sectional study was done throughout one year between 2015-2016 in GDM patients (age, 20-40 years). After history taking and physical examination, the laboratory tests including : Fasting Blood Sugar (FBS), Glucose Tolerance Test (GTT), calcium, phosphorous, parathormone, 25(OH) vitamin D, insulin, HbA1C, TG, LDL, HDL were performed for all patients. Insulin resistance was calculated according to HOMA-IR formula. Vitamin D level was compared between patients with and without insulin resistance.
This research was performed in 93 GDM patients with average age (30.3 ± 5.6). Thirty eight patients with insulin resistance and 55 patients without insulin resistance were detected. The prevalence of vitamin D deficiency was 91.4% in all patients. There was no significant difference in vitamin D levels between insulin resistant and non insulin resistant group (P-value=0.51). In all variable parameters, only FBS and triglyceride level in insulin resistant group were more than non insulin resistant group (P-value<0.05).
Obtained results showed not significant relationship between vitamin D deficiency and insulin resistance in GDM patients.
糖尿病是妊娠期最常见的医学病症之一。维生素D缺乏作为糖耐量受损发病机制的可能性表明维生素D在胰岛素分泌和降低胰岛素抵抗方面可能发挥作用。本研究旨在评估妊娠期糖尿病（GDM）患者血清维生素D水平与胰岛素抵抗之间的关系。
本横断面研究于2015年至2016年期间对GDM患者（年龄20 - 40岁）进行了为期一年的研究。在进行病史采集和体格检查后，对所有患者进行了实验室检查，包括：空腹血糖（FBS）、葡萄糖耐量试验（GTT）、钙、磷、甲状旁腺激素、25（OH）维生素D、胰岛素、糖化血红蛋白（HbA1C）、甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）。根据HOMA - IR公式计算胰岛素抵抗。比较有胰岛素抵抗和无胰岛素抵抗患者的维生素D水平。
本研究共纳入93例平均年龄为（30.3±5.6）岁的GDM患者。检测到38例有胰岛素抵抗患者和55例无胰岛素抵抗患者。所有患者中维生素D缺乏的患病率为91.4%。胰岛素抵抗组和非胰岛素抵抗组的维生素D水平无显著差异（P值 = 0.51）。在所有可变参数中，只有胰岛素抵抗组的空腹血糖和甘油三酯水平高于非胰岛素抵抗组（P值<0.05）。
所得结果表明GDM患者中维生素D缺乏与胰岛素抵抗之间无显著关系。
