MOG-IgG 相关疾病中 IgM 和 IgA 抗 MOG 的频率和相关性。
Frequency and relevance of IgM, and IgA antibodies against MOG in MOG-IgG-associated disease.
机构信息
Neuroimmunology Program, Institut d' Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Neuroimmunology Program, Institut d' Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Unitat de Neuroimmunologia-Esclerosi múltiple, Servei de Neurología, Hospital Clinic, and Universitat de Barcelona, Barcelona, Spain.
出版信息
Mult Scler Relat Disord. 2019 Feb;28:230-234. doi: 10.1016/j.msard.2019.01.007. Epub 2019 Jan 3.
OBJECTIVE
To determine the frequency and relevance of IgM, and IgA antibodies against myelin oligodendrocyte glycoprotein (MOG) in MOG-IgG-associated disease.
METHODS
Evaluation of IgM, and IgA MOG antibodies in serum of 120 patients with MOG-IgG (53 pediatric and 67 adults), and 114 patients with seronegative-MOG-IgG (35 children with first demyelinating syndrome, 20 adults with clinically isolated syndrome, and 59 adults with other diseases). Antibodies were examined by cell-based assays.
RESULTS
IgM or IgA MOG antibodies were identified in 23/120 (19%) patients with MOG-IgG (13/53 [24.5%] pediatric, and 10/67 [15%] adult patients), and 2/114 (1.7%) patients with seronegative-MOG-IgG (2/35 [5.7%] pediatric patients). Of the 25 patients, 14 had IgA, 9 IgM, and 2 both antibodies. Fourteen of the 15 (93%) children with IgM (4), IgA (9), or both (2) had acute demyelinating encephalomyelitis (ADEM), and 7 of the 10 (70%) adults with IgM (5) or IgA (5) had optic neuritis at onset. At the last follow-up, the final diagnoses remained as ADEM in 14 (100%) children and optic neuritis in 6 (86%) adults. The outcome was not different between patients with or without additional classes of antibodies.
CONCLUSION
Coexisting IgM and IgA antibodies occurs in 19% of children and adult patients with MOG-IgG-associated disease. The presence of these antibodies does not seem to play a relevant clinical role in the disorder.
目的
确定髓鞘少突胶质细胞糖蛋白（MOG）免疫球蛋白 M（IgM）和免疫球蛋白 A（IgA）抗体在 MOG-IgG 相关疾病中的频率和相关性。
方法
评估 120 例 MOG-IgG（53 例儿科和 67 例成人）和 114 例 MOG-IgG 阴性患者（35 例首发脱髓鞘综合征儿童、20 例临床孤立综合征成人和 59 例其他疾病成人）血清中的 IgM 和 IgA MOG 抗体。通过细胞为基础的检测方法进行抗体检测。
结果
在 120 例 MOG-IgG 患者（53 例儿科，67 例成人）中有 23 例（19%）发现 IgM 或 IgA MOG 抗体，在 114 例 MOG-IgG 阴性患者中有 2 例（1.7%）发现（2 例儿科患者）。在 25 例患者中，有 14 例为 IgA，9 例为 IgM，2 例为两种抗体。15 例有 IgM（4 例）、IgA（9 例）或两种抗体（2 例）的儿童中，14 例（93%）患有急性播散性脑脊髓炎（ADEM），10 例有 IgM（5 例）或 IgA（5 例）的成人中有 7 例（70%）患有视神经炎。在最后一次随访时，14 例儿童的最终诊断仍为 ADEM，6 例成人的最终诊断仍为视神经炎。有无其他类型抗体的患者之间的预后无差异。
结论
MOG-IgG 相关疾病的儿童和成年患者中存在同时存在 IgM 和 IgA 抗体，这些抗体的存在在该疾病中似乎没有发挥重要的临床作用。
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