Cancer Hospital I, National Cancer Institute, Rio de Janeiro, Brazil.
Research Center, National Cancer Institute, Rio de Janeiro, Brazil.
Future Oncol. 2019 Feb;15(5):485-494. doi: 10.2217/fon-2018-0613. Epub 2019 Jan 9.
Estimate the incidence of bone metastases (BM) and skeletal-related events according to the histological subtype of lung cancer and its impact on patient survival.
PATIENTS & METHODS: Retrospective cohort study was carried out with patients diagnosed with lung cancer. Cumulative incidence, Kaplan-Meier survival analysis and the risk of death were estimated.
In non-small-cell lung cancer (NSCLC), the cumulative incidence of BM during follow-up was 23.8% at 24 months; in small-cell lung cancer, it was 18.5%. The presence of BM in patients with NSCLC was associated with an increased risk of death (hazard ratio: 1.25; 95% CI: 1.04-1.49; p = 0.013).
This study revealed a high incidence of BM and skeletal-related events. BM was associated with a poor prognosis in NSCLC patients.
根据肺癌的组织学亚型及其对患者生存的影响，估算骨转移（BM）和骨骼相关事件的发生率。
对诊断为肺癌的患者进行回顾性队列研究。估计累积发生率、Kaplan-Meier 生存分析和死亡风险。
在非小细胞肺癌（NSCLC）中，24 个月时 BM 的累积发生率为 23.8%；在小细胞肺癌中，为 18.5%。NSCLC 患者存在 BM 与死亡风险增加相关（风险比：1.25；95%CI：1.04-1.49；p=0.013）。
本研究显示 BM 和骨骼相关事件的发生率较高。BM 与 NSCLC 患者的不良预后相关。
