Kesner R P
Department of Psychology, University of Utah, Salt Lake City 84112.
Neurobiol Aging. 1988 Sep-Dec;9(5-6):609-16. doi: 10.1016/s0197-4580(88)80122-2.
In this review the relationship between the basal forebrain cholinergic system and memory is explored. It appears that different components of the cholinergic forebrain system [e.g., medial septum (MS) and nucleus basalis magnocellularis (NBM)] have dissociable mnemonic functions in animals, and comparable mnemonic functions in humans are dissociable as well. Furthermore, the cholinergic input from MS to the hippocampus and NBM to basolateral amygdala appear to be of critical importance in mediating mnemonic function. Finally, comparable impairments in memory function are found in basal forebrain-damaged rats and patients with dementia of the Alzheimer's type, suggesting that there might be important homologies between animals and humans in terms of basal forebrain-mediated memory function.
在本综述中，探讨了基底前脑胆碱能系统与记忆之间的关系。胆碱能前脑系统的不同组成部分[如内侧隔核（MS）和大细胞基底核（NBM）]在动物中似乎具有可分离的记忆功能，在人类中类似的记忆功能也可分离。此外，从MS到海马以及从NBM到基底外侧杏仁核的胆碱能输入在介导记忆功能方面似乎至关重要。最后，在基底前脑受损的大鼠和阿尔茨海默病型痴呆患者中发现了类似的记忆功能损害，这表明在基底前脑介导的记忆功能方面，动物和人类之间可能存在重要的同源性。
