Monosov Ilya E, Leopold David A, Hikosaka Okihide
Department of Anatomy and Neurobiology, Washington University, School of Medicine, St. Louis, Missouri 63110, Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, Maryland, 20892, and
Section on Cognitive Neurophysiology and Imaging, National Institute of Mental Health, Bethesda, Maryland 20892, Neurophysiology Imaging Facility, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Eye Institute, Bethesda, Maryland 20892.
J Neurosci. 2015 May 13;35(19):7443-59. doi: 10.1523/JNEUROSCI.0051-15.2015.
It has been suggested that the basal forebrain (BF) exerts strong influences on the formation of memory and behavior. However, what information is used for the memory-behavior formation is unclear. We found that a population of neurons in the medial BF (medial septum and diagonal band of Broca) of macaque monkeys encodes a unique combination of information: reward uncertainty, expected reward value, anticipation of punishment, and unexpected reward and punishment. The results were obtained while the monkeys were expecting (often with uncertainty) a rewarding or punishing outcome during a Pavlovian procedure, or unexpectedly received an outcome outside the procedure. In vivo anterograde tracing using manganese-enhanced MRI suggested that the major recipient of these signals is the intermediate hippocampal formation. Based on these findings, we hypothesize that the medial BF identifies various contexts and outcomes that are critical for memory processing in the hippocampal formation.
有人提出，基底前脑（BF）对记忆和行为的形成有强大影响。然而，用于记忆-行为形成的信息尚不清楚。我们发现，猕猴内侧基底前脑（内侧隔核和布罗卡斜带）中的一群神经元编码了一种独特的信息组合：奖励不确定性、预期奖励值、惩罚预期以及意外奖励和惩罚。这些结果是在猴子在经典条件反射过程中期待（通常带有不确定性）奖励或惩罚结果，或意外收到该过程之外的结果时获得的。使用锰增强MRI进行的体内顺行示踪表明，这些信号的主要接收者是海马中间结构。基于这些发现，我们推测内侧基底前脑识别对海马结构中记忆处理至关重要的各种情境和结果。
