Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, 02114, USA.
Adv Healthc Mater. 2019 Feb;8(3):e1801409. doi: 10.1002/adhm.201801409. Epub 2019 Jan 9.
Otitis media with effusion (OEM) is a common pediatric pathology treated with topical fluoroquinolones (ear drops) and tympanoplasty tube, also referred to as ear tube, implantation for middle ear drainage. Commercially available ear tubes are fabricated using poly (lactic-co-glycolic acid) synthetic materials that are associated with long-complications due to premature extrusion. Resorbable materials have emerged as desirable alternatives to reduce extrusion-related complications, but often limited by fast resorption rates. Therefore, resorbable tubes with long-term functional integrity are required for future clinical translation. In this communication, a proof-of-concept study is reported on a bioresorbable and drug-eluting silk ear tube device. Preliminary in vitro assessments reveal time-dependent drug elution and antimicrobial properties, while maintaining long-term functional integrity in vivo. This report provides evidence of a silk ear tube with potential for future clinical translation and OEM treatment.
分泌性中耳炎（OEM）是一种常见的儿科病理，采用局部氟喹诺酮类药物（滴耳液）和鼓室成形术管（也称为耳管）进行治疗，以实现中耳引流。市售的耳管是由聚（乳酸-共-羟基乙酸）合成材料制成的，由于过早挤出，这些材料与长期并发症有关。可吸收材料已成为减少挤出相关并发症的理想替代品，但通常受到快速吸收速率的限制。因此，需要具有长期功能完整性的可吸收管来进行未来的临床转化。在本通讯中，报告了一种生物可吸收和药物洗脱丝质耳管装置的概念验证研究。初步的体外评估显示了时间依赖性药物洗脱和抗菌性能，同时在体内保持长期的功能完整性。本报告提供了一种具有未来临床转化和 OEM 治疗潜力的丝质耳管的证据。
