Cheng Gu, Davoudi Zahra, Xing Xin, Yu Xin, Cheng Xin, Li Zubing, Deng Hongbing, Wang Qun
Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), and Key Laboratory of Oral Biomedicine, Ministry of Education, Wuhan University, Wuhan 430079, China.
Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, School of Resource and Environmental Science, Wuhan University, Wuhan 430079, China.
ACS Biomater Sci Eng. 2018 Aug 13;4(8):2704-2715. doi: 10.1021/acsbiomaterials.8b00150. Epub 2018 Jul 19.
Silk fibroin is regarded as a natural fibrous protein with tunable mechanical properties, acceptable biocompatibility, and favorable capability of enhancing attachment, proliferation, and differentiation of chondrocytes. These properties make it suitable for the fabrication of scaffolds and a broad range of silk fibroin-based biomaterials for cartilage regenerative therapy, which can heal functional cartilage without scar tissue. It can be used as a single material for making different kinds of scaffolds or as a composite with other types of biomaterials. Together with some growth factors, silk fibroin scaffolds can form a support for the growth and differentiation of seeding cells, such as chondrogenic lineage cells and mesenchymal stem cells. Recent advancements of silk fibroin in cartilage regeneration are summarized in this review. Furthermore, the manufacturing methods of silk fibroin materials and their applications in the regeneration of cartilage are also discussed.
丝素蛋白被视为一种天然纤维蛋白，具有可调节的机械性能、可接受的生物相容性以及促进软骨细胞附着、增殖和分化的良好能力。这些特性使其适用于制造支架以及广泛的用于软骨再生治疗的丝素蛋白基生物材料，从而能够在无瘢痕组织的情况下修复功能性软骨。它既可以作为单一材料用于制造不同类型的支架，也可以与其他类型的生物材料复合使用。丝素蛋白支架与一些生长因子一起，可以为种子细胞（如软骨谱系细胞和间充质干细胞）的生长和分化形成支撑。本文综述了丝素蛋白在软骨再生方面的最新进展。此外，还讨论了丝素蛋白材料的制造方法及其在软骨再生中的应用。
