三键插入引发钯催化的C-N键活化使偕胺肟对1,3-烯炔进行高度区域选择性的1,4-氨甲基化反应。
Triple-Bond Insertion Triggers Highly Regioselective 1,4-Aminomethylamination of 1,3-Enynes with Aminals Enabled by Pd-Catalyzed C-N Bond Activation.
作者信息
Zhang Yanchen, Yu Bangkui, Gao Binjian, Zhang Tianze, Huang Hanmin
机构信息
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis , University of Science and Technology of China , Chinese Academy of Sciences, Hefei 230026 , P.R. China.
State Key Laboratory of Applied Organic Chemistry , Lanzhou University , Lanzhou 730000 , P.R. China.
出版信息
Org Lett. 2019 Jan 18;21(2):535-539. doi: 10.1021/acs.orglett.8b03847. Epub 2019 Jan 9.
A highly chemo- and regioselective 1,4-aminomethylamination of simple enynes with aminals to allenic 1,5-diamines by taking advantage of C-N bond activation has been reported. The reaction proceeds under mild reaction conditions and can be performed under lower catalyst loading (0.1 mol %) with high efficiency and broad substrate scope.
据报道，利用C-N键活化，简单烯炔与缩醛胺可进行高度化学选择性和区域选择性的1,4-氨甲基化反应，生成联烯型1,5-二胺。该反应在温和的反应条件下进行，可在较低催化剂负载量（0.1 mol%）下高效进行，且底物范围广泛。
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