Zhang Yanchen, Yu Bangkui, Gao Binjian, Zhang Tianze, Huang Hanmin
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis , University of Science and Technology of China , Chinese Academy of Sciences, Hefei 230026 , P.R. China.
State Key Laboratory of Applied Organic Chemistry , Lanzhou University , Lanzhou 730000 , P.R. China.
Org Lett. 2019 Jan 18;21(2):535-539. doi: 10.1021/acs.orglett.8b03847. Epub 2019 Jan 9.
A highly chemo- and regioselective 1,4-aminomethylamination of simple enynes with aminals to allenic 1,5-diamines by taking advantage of C-N bond activation has been reported. The reaction proceeds under mild reaction conditions and can be performed under lower catalyst loading (0.1 mol %) with high efficiency and broad substrate scope.
据报道，利用C-N键活化，简单烯炔与缩醛胺可进行高度化学选择性和区域选择性的1,4-氨甲基化反应，生成联烯型1,5-二胺。该反应在温和的反应条件下进行，可在较低催化剂负载量（0.1 mol%）下高效进行，且底物范围广泛。
