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级联 Sonogashira 交叉偶联-取代-消除反应合成线性共轭二炔。

A Cascade Sonogashira Cross-Coupling-Substitution-Elimination Reaction for the Synthesis of Linear Conjugated Dienynes.

机构信息

Instituto de Tecnología Química (UPV-CSIC), Universidad Politècnica de València-Consejo Superior de Investigaciones Científicas, Avda. de los Naranjos s/n, 46022, Valencia, Spain.

出版信息

Chemistry. 2022 Dec 20;28(71):e202202421. doi: 10.1002/chem.202202421. Epub 2022 Oct 31.

DOI:10.1002/chem.202202421
PMID:36134576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10092193/
Abstract

The engagement in tandem of well-known organic reactions such as the Pd-catalyzed Sonogashira cross-coupling reaction, nucleophilic substitution and elimination reactions, enables the synthesis of otherwise difficult to obtain linear dienynes, in moderate to high yields. This retrosynthetic approach opens new ways to prepare highly conjugated alkenes and alkynes. Furthermore, ionic liquids are suitable solvents to perform the cascade reaction and recycle the metal catalysts.

摘要

通过 Pd 催化的 Sonogashira 交叉偶联反应、亲核取代和消除反应等著名有机反应的串联反应，可以以中等至较高的收率合成原本难以获得的线性二炔，这种反合成方法为制备高共轭烯烃和炔烃开辟了新途径。此外，离子液体是进行级联反应和回收金属催化剂的合适溶剂。

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Photoinduced Palladium-Catalyzed Dicarbofunctionalization of Terminal Alkynes.光诱导钯催化末端炔烃的双官能化反应。
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Fe-Catalyzed Selective Cyclopropanation of Enynes under Photochemical or Thermal Conditions.铁催化烯炔在光化学或热条件下的选择性环丙烷化反应
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