Maksimovskiĭ L F
Ontogenez. 1988 Sep-Oct;19(5):461-7.
The current ideas about realization of all the genetic information via stage-specific transcription and translation do not account for morphogenetic processes in space. The physical continuity of some cellular structures is only one of the mechanisms underlying the inheritance of morphofunctional properties. A suggestion was put forward that morphogenetic information is contained in nontranscribed DNA sequences. Specific interaction of these sequences with each other and with the nuclear membrane determine the spatial organization of the nucleus and program the functional properties of the endoplasmic reticulum membranes. Interaction between the nucleus and other cell structures, its localization and orientation determine the cell's polar properties and, consequently, morphogenesis of tissues and organs.
目前关于通过阶段特异性转录和翻译实现所有遗传信息的观点并未考虑空间中的形态发生过程。某些细胞结构的物理连续性只是形态功能特性遗传的潜在机制之一。有人提出形态发生信息包含在非转录DNA序列中。这些序列彼此之间以及与核膜的特异性相互作用决定了细胞核的空间组织，并规划了内质网膜的功能特性。细胞核与其他细胞结构之间的相互作用、其定位和方向决定了细胞的极性特性，进而决定了组织和器官的形态发生。
