Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei 430030, China.
Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, #100 Hongkong Road, Wuhan, Hubei 430030, China.
Sci Total Environ. 2019 Mar 15;656:1102-1107. doi: 10.1016/j.scitotenv.2018.11.305. Epub 2018 Nov 22.
An increasing number of epidemiological studies have shown that daily hot and cold temperatures are associated with preterm birth (PTB). However, the relationship between daily temperature variation and PTB is poorly understood.
This study aimed to investigate the role of prenatal exposure to diurnal temperature range (DTR), the difference between the daily maximum and minimum temperatures, in the risk of PTB.
A total of 11,056 women who gave birth to a live singleton infant were recruited from the Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), from September 2012 to October 2014. Daily temperature data were obtained from the official website of China Meteorological Administration. A binary logistic regression model was used to estimate the association between DTR and PTB.
Among the 11,056 live singleton births, 618 (5.6%) infants were PTB. Prenatal exposure to large DTR during the second week before delivery was significantly associated with an increased risk of PTB. After adjusting for the daily mean temperature, daily mean humidity, socioeconomic, obstetrical and lifestyle factors, each 1 °C incremental increase in DTR was associated with a 5.4% (95% CIs: 1.006, 1.104; P = 0.026) increased risk of PTB. The association between large DTR exposure and PTB was stronger for pregnant women with a higher pre-pregnancy BMI, older maternal age, and with delivery in cold season.
This is the first study to reveal the association between DTR and PTB in China. Health professionals and pregnant women should be aware of the influence of unstable temperature conditions on the risk of PTB.
越来越多的流行病学研究表明，每日的冷热温度与早产（PTB）有关。然而，每日温度变化与 PTB 之间的关系尚不清楚。
本研究旨在探讨产前暴露于日较差（DTR），即每日最高温度与最低温度之间的差异，与 PTB 风险的关系。
2012 年 9 月至 2014 年 10 月，我们从武汉儿童医院（武汉市妇幼保健院）招募了 11056 名分娩活单胎婴儿的妇女。每日温度数据来自中国气象局官方网站。使用二元逻辑回归模型估计 DTR 与 PTB 之间的关联。
在 11056 例活产单胎中，有 618 例（5.6%）婴儿为 PTB。分娩前第二周暴露于较大的 DTR 与 PTB 风险增加显著相关。在调整每日平均温度、平均湿度、社会经济、产科和生活方式因素后，DTR 每增加 1°C，PTB 的风险增加 5.4%（95%CI：1.006，1.104；P=0.026）。对于孕前 BMI 较高、母亲年龄较大以及分娩在寒冷季节的孕妇，较大的 DTR 暴露与 PTB 之间的关联更强。
这是第一项在中国揭示 DTR 与 PTB 之间关联的研究。卫生专业人员和孕妇应意识到不稳定的温度条件对 PTB 风险的影响。
