Yoon Do Geun, Jung Sang Ho, Ha Myung Hwa, Song Nam Won
Department of Anesthesiology and Pain Medicine, Maryknoll Hospital, Busan, Korea.
Korean J Anesthesiol. 2009 Apr;56(4):408-412. doi: 10.4097/kjae.2009.56.4.408.
In this randomized, double-blinded study, we evaluated the efficacy of ramosetron and ondansetron for preventing postoperative nausea and vomiting (PONV) after middle ear surgery.
Seventy patients of either sex, ASA 1-2, scheduled middle ear surgery (mastoidectomy and tympanoplasty) under general anesthesia with sevoflurane and remifentanil were included. Patients were randomly divided into two groups and received IV ramosetron 0.3 mg (group R) or ondansetron 4 mg (group O) before the end of operation (n = 35 each). The incidence and severity of PONV, pain score (VAS), rescue antiemetic, rescue analgesic and side effects were assessed following 6 hr, 24 hr and 48 hr after surgery.
The incidence of PONV showed no significant difference between groups at each time points after surgery. There were no difference in the severity of nausea, pain score, rescue antiemetic, analgesic drug usage and side effects between groups.
Prophylactic therapy with ramosetron is as effective and safe as conventional prophylactic therapy with ondansetron for preventing PONV in patients undergoing general anesthesia for middle ear surgery.
在这项随机双盲研究中，我们评估了雷莫司琼和昂丹司琼预防中耳手术后恶心和呕吐（PONV）的疗效。
纳入70例年龄、性别不限、ASA分级为1-2级、计划在七氟醚和瑞芬太尼全身麻醉下进行中耳手术（乳突切除术和鼓室成形术）的患者。患者随机分为两组，在手术结束前分别静脉注射0.3mg雷莫司琼（R组）或4mg昂丹司琼（O组）（每组n = 35）。术后6小时、24小时和48小时评估PONV的发生率和严重程度、疼痛评分（VAS）、补救性止吐药、补救性镇痛药及副作用。
术后各时间点两组间PONV发生率无显著差异。两组间恶心严重程度、疼痛评分、补救性止吐药、镇痛药使用及副作用无差异。
对于接受中耳手术全身麻醉的患者，雷莫司琼预防性治疗在预防PONV方面与传统的昂丹司琼预防性治疗同样有效且安全。
