Cutfield Samuel W, Wickremesekera Agadha C, Mantamadiotis Theo, Kaye Andrew H, Tan Swee T, Stylli Stanley S, Itineang Tinte
Gillies McIndoe Research Institute, Wellington, New Zealand; Department of Neurosurgery, Wellington Regional Hospital, Wellington, New Zealand.
Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia; Department of Microbiology & Immunology, School of Biomedical Sciences, The University of Melbourne, Melbourne, Victoria 3000, Australia.
J Clin Neurosci. 2019 Apr;62:21-26. doi: 10.1016/j.jocn.2018.12.022. Epub 2019 Jan 6.
Schwannoma is a peripheral nerve tumour, accounting for 5% of benign soft tissue tumours, with vestibular schwannoma comprising 6% of all intracranial tumours. The tumour stem cell concept is rapidly gaining traction underscoring the understanding of tumourigenesis. It proposes a small subpopulation of primitive cells as the origin of the tumour and these cells account for treatment resistance, local recurrence and distant metastasis in malignant tumours. This review outlines the stem cell markers used to identify and characterise stem cells and progenitor cells in tumours and examines current evidence of the presence of tumour stem cells in schwannoma.
施万细胞瘤是一种周围神经肿瘤，占良性软组织肿瘤的5%，其中前庭施万细胞瘤占所有颅内肿瘤的6%。肿瘤干细胞概念正在迅速获得认可，这突出了对肿瘤发生的理解。它提出一小群原始细胞是肿瘤的起源，这些细胞导致恶性肿瘤的治疗抵抗、局部复发和远处转移。这篇综述概述了用于识别和表征肿瘤中的干细胞和祖细胞的干细胞标志物，并研究了目前关于施万细胞瘤中存在肿瘤干细胞的证据。
