Rao M S, Chaudhuri B, Scarpelli D G
J Pathol. 1981 Nov;135(3):169-77. doi: 10.1002/path.1711350302.
A human malignant Schwannoma was serially transplanted through three generations in nude mice. The tumours grew readily and the take-up rate was 100 per cent. No metastasis was observed in nude mice. Morphological features of the original tumour were strictly maintained through all the transplant generations. The tumour cells of the original and of the transplants showed features of primitive Schwann cells of embryonic nerve trunks.
将一例人类恶性神经鞘瘤在裸鼠中连续传代移植了三代。肿瘤易于生长，接种率为100%。在裸鼠中未观察到转移。原始肿瘤的形态学特征在所有移植代中都得到严格保持。原始肿瘤和移植肿瘤的细胞均显示出胚胎神经干原始施万细胞的特征。
