有丝分裂细胞分裂在 。
Mitotic Cell Division in .
机构信息
Equipe labellisée Ligue contre le Cancer, Institut Jacques Monod, Team Cell Cycle and Development UMR7592, Centre National de la Recherche Scientifique - Université Paris Diderot, Sorbonne Paris Cité, 75013 Paris, France
Institute of Molecular Biology, University of Oregon, Eugene, OR 97403
出版信息
Genetics. 2019 Jan;211(1):35-73. doi: 10.1534/genetics.118.301367.
Abstract
Mitotic cell divisions increase cell number while faithfully distributing the replicated genome at each division. The embryo is a powerful model for eukaryotic cell division. Nearly all of the genes that regulate cell division in are conserved across metazoan species, including humans. The pathways tend to be streamlined, facilitating dissection of the more redundant human pathways. Here, we summarize the virtues of as a model system and review our current understanding of centriole duplication, the acquisition of pericentriolar material by centrioles to form centrosomes, the assembly of kinetochores and the mitotic spindle, chromosome segregation, and cytokinesis.
摘要
有丝分裂细胞分裂增加细胞数量，同时在每次分裂时忠实地分配复制的基因组。胚胎是真核细胞分裂的有力模型。几乎所有调节细胞分裂的基因在后生动物物种中都被保守，包括人类。这些途径往往被简化，有利于解析更冗余的人类途径。在这里，我们总结了作为模型系统的优点，并回顾了我们目前对中心粒复制、中心粒获得构成中心体的周围物质、动粒和纺锤体的组装、染色体分离和胞质分裂的理解。
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Mitotic Cell Division in .有丝分裂细胞分裂在 。
Genetics. 2019 Jan;211(1):35-73. doi: 10.1534/genetics.118.301367.
2
Cell division.细胞分裂
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本文引用的文献
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Combinatorial Contact Cues Specify Cell Division Orientation by Directing Cortical Myosin Flows.组合接触线索通过指导皮质肌球蛋白流来指定细胞分裂方向。
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CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytia.CYK-4 可独立于其中心纺锤体伴侣 ZEN-4 发挥功能，使生殖细胞合胞体中的卵母细胞细胞化。
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A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in .一种基于正反馈的机制，用于细胞分裂过程中收缩率的加速。
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Microtubule Dynamics Scale with Cell Size to Set Spindle Length and Assembly Timing.微管动力学与细胞大小成比例，以设定纺锤体长度和组装时间。
Dev Cell. 2018 May 21;45(4):496-511.e6. doi: 10.1016/j.devcel.2018.04.022.
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The XMAP215 Ortholog Alp14 Promotes Microtubule Nucleation in Fission Yeast.XMAP215 同源物 Alp14 促进裂殖酵母中的微管成核。
Curr Biol. 2018 Jun 4;28(11):1681-1691.e4. doi: 10.1016/j.cub.2018.04.008. Epub 2018 May 17.
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Spatiotemporal Regulation of RhoA during Cytokinesis.有丝分裂中 RhoA 的时空调节。
Curr Biol. 2018 May 7;28(9):R570-R580. doi: 10.1016/j.cub.2018.03.045.
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XMAP215 is a microtubule nucleation factor that functions synergistically with the γ-tubulin ring complex.XMAP215 是一种微管成核因子，与 γ-微管蛋白环复合物协同作用。
Nat Cell Biol. 2018 May;20(5):575-585. doi: 10.1038/s41556-018-0091-6. Epub 2018 Apr 25.
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Mitotic spindles revisited - new insights from 3D electron microscopy.重新审视有丝分裂纺锤体——来自 3D 电子显微镜的新见解。
J Cell Sci. 2018 Jan 30;131(3):jcs211383. doi: 10.1242/jcs.211383.
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TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis.TPXL-1 通过激活 Aurora A，在胞质分裂过程中从极性皮层中清除收缩环成分。
J Cell Biol. 2018 Mar 5;217(3):837-848. doi: 10.1083/jcb.201706021. Epub 2018 Jan 8.
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ZYG-1 promotes limited centriole amplification in the C. elegans seam lineage.ZYG-1在秀丽隐杆线虫的表皮细胞谱系中促进有限的中心粒扩增。
Dev Biol. 2018 Feb 15;434(2):221-230. doi: 10.1016/j.ydbio.2018.01.001. Epub 2018 Jan 4.
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