Farmani Farzaneh, Farhadi Hadi, Mohammadi Younes
MSc Student, Department of Psychology, School of Educational Sciences and Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Assistant Professor, Department of Psychology, School of Educational Sciences and Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Addict Health. 2018 Jan;10(1):41-51. doi: 10.22122/ahj.v10i1.488.
This comprehensive systematic review and meta-analysis were performed to assess the associated factors of maintenance in patients with methadone therapy in the world.
A systematic literature review was performed from several scientific databases; these include PubMed, Scopus, ISI Web of Science, and MEDLINE. We searched the following keywords: "Methadone", "Maintenance", "Retention", "Meta-analysis" and "Associated factors". Data were selected based on the inclusion and exclusion criteria. The purpose of this study was to assess the associated factors of maintenance in patients under treatment with methadone by an overall effect size, odds ratio (OR) [95% confidence interval (CI)] using meta-analysis.
We selected 24 researches out of 94413 for our study based on the inclusion and exclusion criteria for systematic review and meta-analysis. The pooled recognized five significant positive associations of age, marital status, employment status, gender, and length of treatment with methadone usage (OR age = 3.566, 95% CI = 3.296-3.836, P < 0.001; OR marital status = 1.101, 95% CI = 1.028-1.175, P = 0.025; OR employment = 1.157, 95% CI = 1.060-1.254, P = 0.015; OR gender = 4.686, 95% CI = 4.434-4.939, P < 0.001; OR duration of treatment = 1.543, 95% CI = 1.443-1.647, P < 0.001; respectively). However, education and injection status showed a non-significant positive association with methadone usage (OR education level = 1.279, 95% CI = 0.976-1.583, P = 0.266; OR injection status = 1.205, 95% CI = 0.725-1.658, P = 0.442).
This systematic-review and meta-analysis study displayed that factors such as age, marital and employment status, gender, and duration of treatment are effective on maintenance in patients under treatment of methadone.
本项综合性系统评价和荟萃分析旨在评估全球接受美沙酮治疗患者维持治疗的相关因素。
从多个科学数据库进行系统的文献检索，包括PubMed、Scopus、ISI Web of Science和MEDLINE。我们检索了以下关键词：“美沙酮”“维持治疗”“保留率”“荟萃分析”和“相关因素”。根据纳入和排除标准选择数据。本研究的目的是通过荟萃分析，以总体效应量、比值比（OR）[95%置信区间（CI）]评估接受美沙酮治疗患者维持治疗的相关因素。
根据系统评价和荟萃分析的纳入和排除标准，我们从94413项研究中筛选出24项用于本研究。汇总分析确定了年龄、婚姻状况、就业状况、性别和治疗时长与美沙酮使用之间存在5个显著的正相关关系（年龄的OR = 3.566，95%CI = 3.296 - 3.836，P < 0.001；婚姻状况的OR = 1.101，95%CI = 1.028 - 1.175，P = 0.025；就业状况的OR = 1.157，95%CI = 1.060 - 1.254，P = 0.015；性别的OR = 4.686，95%CI = 4.434 - 4.939，P < 0.001；治疗时长的OR = 1.543，95%CI = 1.443 - 1.647，P < 0.001）。然而，教育程度和注射情况与美沙酮使用呈非显著正相关（教育程度的OR = 1.279，95%CI = 0.976 - 1.583，P = 0.266；注射情况的OR = 1.205，95%CI = 0.725 - 1.658，P = 0.442）。
本系统评价和荟萃分析研究表明，年龄、婚姻和就业状况、性别以及治疗时长等因素对接受美沙酮治疗患者的维持治疗有影响。
