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电刺激大鼠下丘脑外侧区所驱动的单个神经元的强度-时间特性

Strength-duration properties of single units driven by electrical stimulation of the lateral hypothalamus in rats.

作者信息

Matthews G

出版信息

Brain Res Bull. 1978 Mar-Apr;3(2):171-4. doi: 10.1016/0361-9230(78)90043-6.

DOI:10.1016/0361-9230(78)90043-6
PMID:306275
Abstract

Cathodal strength-duration functions were measured for 27 single units which were driven by electrical stimulation of the lateral hypothalamus. The distribution of chronaxies of these units showed four clusters at about 0.1, 0.25, 0.4 and 0.5 msec. These chronaxies are not fundamentally different from those previously reported for peripheral nerve. Two units fired repetitively during a long-duration stimulation pulse. Anodal strengitation. The data are discussed with reference to behaviorally determith duration properties were obtained from 14 units. Four units were not excited by anodal pulses of any strength or duration, four were excited during an anodal pulse (anode-make excitation) but not at the termination of the pulse (anode-break excitation), and six showed both anode-make and anode-break excitation. The data are discussed with reference to behaviorally determined strength-duration functions for brain stimulation reward.

摘要

对27个由下丘脑外侧电刺激驱动的单个神经元测量了阴极强度-时间函数。这些神经元的时值分布在约0.1、0.25、0.4和0.5毫秒处显示出四个簇。这些时值与先前报道的外周神经时值没有根本差异。在长时间刺激脉冲期间,有两个神经元重复放电。阳极刺激。从14个神经元获得了阳极刺激的持续时间特性数据。四个神经元对任何强度或持续时间的阳极脉冲都没有反应,四个在阳极脉冲期间(阳极接通刺激)被激发,但在脉冲结束时(阳极断开刺激)没有被激发,六个既表现出阳极接通刺激又表现出阳极断开刺激。结合行为学确定的脑刺激奖赏强度-时间函数对这些数据进行了讨论。

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