Bielajew C, Lapointe M, Kiss I, Shizgal P
Physiol Behav. 1982 Jan;28(1):125-32. doi: 10.1016/0031-9384(82)90113-5.
The pulse-pair paradigm was used to behaviorally assess the absolute and relative refractory periods of neurons subserving brain-stimulation reward. The amplitude of the second pulse was either equal to, 41% greater than, or 73% greater than the amplitude of the first pulse. In the equal amplitude condition, recovery from refractoriness began as early as 0.4 msec and did not asymptote until as late as 3.5 msec. A 41% increase in the intensity shortened the time course of recovery in five out of six cases. In only one of these five cases did a 73% increase in the intensity of the second pulse produce further changes in time course. Neither increase in the amplitude of the second pulse affected the time course of recovery in one subject. The absolute refractory periods of the directly stimulated reward-relevant neurons appear to be less than 1.5 msec and as short as 0.4 msec; some of these neurons have relative refractory periods that range between 1.0 and 3.5 msec.
采用脉冲对范式对介导脑刺激奖赏的神经元的绝对不应期和相对不应期进行行为学评估。第二个脉冲的幅度与第一个脉冲的幅度相等、比第一个脉冲的幅度大41%或大73%。在幅度相等的情况下，从不应期恢复最早在0.4毫秒开始，直到3.5毫秒才渐近。强度增加41%在六分之五的情况下缩短了恢复的时间进程。在这五个案例中，只有一个案例中第二个脉冲强度增加73%使时间进程产生了进一步变化。第二个脉冲幅度的增加均未影响一名受试者的恢复时间进程。直接刺激的奖赏相关神经元的绝对不应期似乎小于1.5毫秒，短至0.4毫秒；其中一些神经元的相对不应期在1.0至3.5毫秒之间。
