Lüscher T F, Yang Z, Diederich D, Schneider K, von Segesser L, Siebenmann R, Stulz P, Bühler F R
Departement für Innere Medizin, Kantonsspital Basel.
Schweiz Med Wochenschr. 1988 Nov 19;118(46):1724-9.
Endothelial cells release a potent vasodilator which activates guanylate cyclase and thereby induces relaxation of vascular smooth muscle cells. The so-called endothelium-derived relaxing factor (EDRF) is released by acetylcholine, local and circulating hormones, and substances released from aggregating platelets or formed during activation of the coagulation cascade. Nitric oxide (NO) probably accounts for the factor's activity. Thus, endothelial cells produce endogenous nitrates causing vasodilatation and inhibition of platelet adhesion and aggregation. Under physiological conditions, EDRF may play a role in the prevention of vasospasm and thrombosis. On the other hand, the impairment of endothelial regulatory mechanisms in atherosclerosis and hypertension may be involved in the pathogenesis of vascular occlusion and thereby of myocardial infarction, stroke and peripheral vascular disease.
内皮细胞释放一种强效血管舒张剂，该物质可激活鸟苷酸环化酶，从而诱导血管平滑肌细胞舒张。所谓的内皮源性舒张因子（EDRF）可由乙酰胆碱、局部和循环激素以及聚集血小板释放的物质或凝血级联激活过程中形成的物质释放出来。一氧化氮（NO）可能是该因子活性的原因。因此，内皮细胞产生内源性硝酸盐，导致血管舒张并抑制血小板黏附和聚集。在生理条件下，EDRF可能在预防血管痉挛和血栓形成中发挥作用。另一方面，动脉粥样硬化和高血压中内皮调节机制的损害可能参与血管闭塞的发病机制，进而参与心肌梗死、中风和外周血管疾病的发病机制。
