Zolotarev V A, Andreeva Yu V, Khropycheva R P
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Bull Exp Biol Med. 2019 Jan;166(3):310-312. doi: 10.1007/s10517-019-04339-w. Epub 2019 Jan 9.
Application of mild irritants (1 M NaCl; pH 2.0) on the gastric mucosa potentiates the protective secretion of bicarbonates by epithelial cells. This response is mainly mediated by capsaicin-sensitive afferent nerve endings located in the submucosa. It was shown that activation of vanilloid type 1 receptors (TRPV1) induced by exogenous acidification of GM is not sufficient to potentiate the production of HCO, including production depending on neuronal NO synthase. However, the effect of exogenous acid on TRPV1 leads to activation of endothelial NO synthase that restrict the gastric secretion of [Formula: see text].
在胃黏膜上施加轻度刺激物（1M氯化钠；pH 2.0）可增强上皮细胞碳酸氢盐的保护性分泌。这种反应主要由位于黏膜下层的辣椒素敏感传入神经末梢介导。研究表明，胃黏膜外源性酸化诱导的香草酸受体1型（TRPV1）激活不足以增强碳酸氢盐的产生，包括依赖神经元型一氧化氮合酶的产生。然而，外源性酸对TRPV1的作用会导致内皮型一氧化氮合酶的激活，从而限制胃[公式：见原文]的分泌。
