Labella Alejandro M, Leiva-Rebollo Rocío, Alejo Alí, Castro Dolores, Borrego Juan J
Universidad de Málaga, Departamento de Microbiología, Campus Universitario Teatinos, 29071 Málaga, Spain.
Dis Aquat Organ. 2019 Jan 10;132(2):151-156. doi: 10.3354/dao03311.
Lymphocystis disease, caused by the iridovirus lymphocystis disease virus (LCDV), is characterized by the appearance of tumour-like lesions on the skin of affected animals associated with several environmental factors and/or with stress due to the intensive culture conditions of fish farms. In a previous study, the genomes of a new LCDV species, LCDV-Sa, were detected, together with 2 previously unknown viruses, Sparus aurata papillomavirus 1 (SaPV1) and Sparus aurata polyomavirus 1 (SaPyV1). Gilthead seabream from 17 fish farms in Spain, Italy and Turkey were sampled between 2009 and 2015 to investigate the role of the newly described SaPV1 and SaPyV1 viruses in lymphocystis disease development. Our results show that in diseased fish, either or both of the new viruses are almost invariably detected together with LCDV (98%). In asymptomatic fish, these viruses were detected in a much lower percentage (28%) and mostly in concurrence with LCDV (24%). These data confirm the suspected association among the 3 different viruses during lymphocystis disease development in gilthead seabream and warrant future studies to establish their respective contributions.
淋巴囊肿病由虹彩病毒淋巴囊肿病病毒（LCDV）引起，其特征是在受感染动物的皮肤上出现肿瘤样病变，这与多种环境因素和/或由于养鱼场集约化养殖条件导致的应激有关。在先前的一项研究中，检测到一种新的LCDV物种LCDV-Sa的基因组，以及两种先前未知的病毒，即金头鲷乳头瘤病毒1（SaPV1）和金头鲷多瘤病毒1（SaPyV1）。2009年至2015年期间，对来自西班牙、意大利和土耳其17个养鱼场的金头鲷进行了采样，以研究新描述的SaPV1和SaPyV1病毒在淋巴囊肿病发展中的作用。我们的结果表明，在患病鱼类中，新病毒中的一种或两种几乎总是与LCDV一起被检测到（98%）。在无症状鱼类中，这些病毒的检测率要低得多（28%），并且大多与LCDV同时出现（24%）。这些数据证实了在金头鲷淋巴囊肿病发展过程中这三种不同病毒之间存在可疑关联，值得未来开展研究以确定它们各自的作用。
