Engineering Technology Research Center for Grain & Oil Food, State Administration of Grain, Zhengzhou 450001, P. R. China.
Org Biomol Chem. 2019 Jan 23;17(4):876-884. doi: 10.1039/c8ob03061h.
A novel and convenient palladium-catalyzed direct oxidative amidation of quinoxalin-2(1H)-ones with acetonitrile was developed to synthesize 3-amidated quinoxalin-2(1H)-ones. A series of 3-acetamino quinoxalin-2(1H)-one derivatives were constructed with good to excellent yields. This methodology provided a practical approach to various 3-acetamino quinoxalin-2(1H)-ones from the readily available starting material acetonitrile.
开发了一种新颖、简便的钯催化喹喔啉-2(1H)-酮与乙腈的直接氧化酰胺化反应，用于合成 3-酰胺基喹喔啉-2(1H)-酮。该方法以良好至优秀的收率构建了一系列 3-乙酰氨基喹喔啉-2(1H)-酮衍生物。该方法为从易得的起始原料乙腈出发制备各种 3-乙酰氨基喹喔啉-2(1H)-酮提供了一种实用的途径。
