School of Chemical Engineering and Technology, Hebei Provincial Key Lab of Green Chemical Technology & High Efficient Energy Saving, Tianjin Key Laboratory of Chemical Process Safety, Hebei University of Technology, Tianjin, 300130, P. R. China.
Chem Asian J. 2020 Oct 16;15(20):3365-3369. doi: 10.1002/asia.202000916. Epub 2020 Sep 21.
Direct sulfonamidation of quinoxalin-2(1H)-one derivatives has been developed using a readily available Cu salt as the catalyst and inexpensive ammonium persulfate as the oxidant in moderate conditions. Owing to the feature of handy operation and good functional group tolerance, this method provides a convenient and efficient access to curative 3-sulfonamidated quinoxalin-2(1H)-one scaffolds.
开发了一种使用易得的铜盐作为催化剂、廉价的过硫酸铵作为氧化剂的喹喔啉-2(1H)-酮衍生物的直接磺酰胺化方法，该方法在温和条件下进行。由于操作简便、官能团容忍性好的特点，该方法为治疗性 3-磺酰胺化喹喔啉-2(1H)-酮支架提供了一种方便、高效的途径。
