State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Int J Oncol. 2019 Mar;54(3):797-806. doi: 10.3892/ijo.2019.4677. Epub 2019 Jan 7.
Fibroblast growth factors (FGFs) are diffusible polypeptides released by a variety of cell types. FGF8 subfamily members regulate embryonic development processes through controlling progenitor cell growth and differentiation, and are also functional in adults in tissue repair to maintain tissue homeostasis. FGF8 family members exhibit unique binding affinities with FGF receptors and tissue distribution patterns. Increasing evidence suggests that, by regulating multiple cellular signaling pathways, alterations in the FGF8 subfamily are involved in craniofacial development, odontogenesis, tongue development and salivary gland branching morphogenesis. Aberrant FGF signaling transduction, caused by mutations as well as abnormal expression or isoform splicing, plays an important role in the development of oral diseases. Targeting FGF8 subfamily members provides a new promising strategy for the treatment of oral diseases. The aim of this review was to summarize the aberrant regulations of FGF8 subfamily members and their potential implications in oral‑maxillofacial diseases.
成纤维细胞生长因子（FGFs）是由多种细胞类型释放的可扩散多肽。FGF8 亚家族成员通过控制祖细胞的生长和分化来调节胚胎发育过程，在组织修复中对成年人也具有功能，以维持组织内稳态。FGF8 家族成员与 FGF 受体表现出独特的结合亲和力和组织分布模式。越来越多的证据表明，FGF8 亚家族的改变通过调节多种细胞信号通路参与颅面发育、牙发生、舌发育和唾液腺分支形态发生。由突变以及异常表达或同工型剪接引起的 FGF 信号转导异常在口腔疾病的发展中起着重要作用。靶向 FGF8 亚家族成员为口腔疾病的治疗提供了一种有前途的新策略。本综述的目的是总结 FGF8 亚家族成员的异常调节及其在口腔颌面疾病中的潜在意义。
