Tribble Jennifer E, Fanselow Michael S
Department of Psychology, University of California, Los Angeles.
Behav Neurosci. 2019 Apr;133(2):232-239. doi: 10.1037/bne0000295. Epub 2019 Jan 10.
Posttraumatic stress disorder (PTSD) is an extremely debilitating disease with a broad array of associated symptoms, making the disorder difficult to diagnose and treat. In humans, patients seem to benefit from group therapy or other means of promoting social behavior. To test these effects on our rodent model of PTSD, adult, male rats were housed in either single or pair conditions prior to and during an acute stressor to induce PTSD-like behaviors in these rats. Subsequently, rats were assessed for PTSD-like symptoms to determine the effect of social housing on stress-induced phenotypes. Posttrauma phenotypes, including enhanced fear conditioning and anxiety-related behavior, persisted regardless of the animal's housing condition. It is possible that any housing driven improvements to stress-induced phenotypes would require longer periods of pair housing than were used in these experiments. Although PTSD patients show improved health outcomes following social interaction or group therapy, the fear and anxiety phenotypes seen following an acute stressor in an animal model of the disease endured despite an animal's housing condition. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
创伤后应激障碍（PTSD）是一种极其使人衰弱的疾病，伴有一系列相关症状，这使得该疾病难以诊断和治疗。在人类中，患者似乎从团体治疗或其他促进社交行为的方式中受益。为了在我们的PTSD啮齿动物模型中测试这些效果，成年雄性大鼠在急性应激源之前和期间被单独或成对饲养，以在这些大鼠中诱导出类似PTSD的行为。随后，对大鼠进行类似PTSD症状的评估，以确定群居对压力诱导表型的影响。创伤后表型，包括增强的恐惧条件反射和焦虑相关行为，无论动物的饲养条件如何都会持续存在。有可能任何由饲养驱动的对压力诱导表型的改善都需要比这些实验中使用的更长时间的成对饲养。尽管PTSD患者在社交互动或团体治疗后健康状况有所改善，但在该疾病的动物模型中，急性应激源后出现的恐惧和焦虑表型无论动物的饲养条件如何都会持续存在。（PsycINFO数据库记录（c）2019美国心理学会，保留所有权利）
