Institute of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Physiol Res. 2019 Apr 30;68(2):321-324. doi: 10.33549/physiolres.934077. Epub 2019 Jan 10.
Induction of cellular cerebral edema (CE) was achieved by a standard method of water intoxication which consisted of fractionated intraperitoneal administration of distilled water (DW) together with the injection of desmopressin (DP). Using metabolic cage, fluid and food balance was studied in two groups of eight animals: group C - control; group CE - cellular edema induced by water intoxication. For each rat the intake (food pellets and water) and excretion (solid excrements and urine) were recorded for 48 h together with the initial and final body weight. CE animals consumed significantly less food, drank less water and eliminated the smallest amount of excrements. The induction of cellular cerebral edema was accompanied with a significant loss of body weight (representing on average 13 % of the initial values) mainly due to a reduction of food intake. This phenomenon has not yet been reported.
诱导细胞性脑水肿（CE）的方法是采用标准的水中毒法，包括分阶段腹腔内给予蒸馏水（DW）和去氨加压素（DP）注射。使用代谢笼，研究了两组 8 只动物的液体和食物平衡：C 组 - 对照组；CE 组 - 由水中毒引起的细胞性脑水肿。对每只大鼠，记录了 48 小时内的摄入（食物颗粒和水）和排泄（固体排泄物和尿液），以及初始和最终体重。CE 动物的食物摄入量显著减少，饮水量减少，排泄的粪便量最少。细胞性脑水肿的诱导伴随着明显的体重减轻（平均占初始值的 13%），主要是由于食物摄入量减少。这种现象尚未有报道。
