Kiefer Johannes
Technische Thermodynamik and MAPEX Center for Materials and Processes , Universität Bremen , Badgasteiner Strasse 1 , 28359 Bremen , Germany.
School of Engineering , University of Aberdeen , Aberdeen AB24 3UE , United Kingdom.
Anal Chem. 2019 Feb 5;91(3):1764-1767. doi: 10.1021/acs.analchem.8b03909. Epub 2019 Jan 24.
Spatially compressed dual-wavelength Raman spectroscopy allows recording the full Raman spectrum using a detection system with limited spectral range. The common approach is to record the spectra with the two excitation lasers consecutively and then concatenate the full spectrum. However, with this approach, quantitative analysis for process monitoring is not possible as the investigated object may change between the two acquisitions. In this Note, spectral fusion is proposed as a concept to overcome this problem. The sample is illuminated by the two lasers simultaneously, hence leading to an on-chip fusion of the different parts of the Raman spectrum. It is shown that the resulting data are suitable for quantitative evaluation using univariate and multivariate methods. Dual-wavelength Raman fusion spectroscopy offers new opportunities for building highly compact devices for analytical chemistry.
空间压缩双波长拉曼光谱法能够使用光谱范围有限的检测系统记录完整的拉曼光谱。常见的方法是依次用两个激发激光记录光谱，然后拼接成全谱。然而，采用这种方法时，由于在两次采集之间被研究对象可能发生变化，因此无法进行用于过程监测的定量分析。在本论文中，提出了光谱融合这一概念来克服这一问题。样品由两个激光同时照射，从而导致拉曼光谱不同部分在芯片上融合。结果表明，所得数据适用于使用单变量和多变量方法进行定量评估。双波长拉曼融合光谱法为构建用于分析化学的高度紧凑设备提供了新机遇。
