Çelik Mustafa, Sökmen Erdoğan, Sivri Serkan, Uçar Cahit, Nar Rukiye, Erer Murat
1 Department of Cardiology, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey.
2 Department of Internal Medicine, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey.
Angiology. 2019 Aug;70(7):662-668. doi: 10.1177/0003319718823625. Epub 2019 Jan 10.
Endothelial dysfunction plays role in the generation of both essential hypertension (EH) and aortic stiffness. We evaluated the relationship between serum endocan level and aortic elastic properties (AEPs) assessed with the aortic strain, aortic distensibility, and aortic stiffness index by echocardiography. Newly diagnosed EH patients (n = 67) and controls (n = 70) were included in the study. The EH group was subdivided into stage 1 and 2 EH groups. A higher endocan level was found in the EH group, compared to the controls (34.2 ± 13.0 vs 24.1 ± 7.3 ng/mL, respectively, < .001). All the AEP parameters were worse in the EH group, compared to the controls. Further, endocan levels correlated with aortic distensibility ( = -0.305, < .001) and aortic strain ( = -0.181, = .038), but not with aortic stiffness index ( = 0.162, = .064) in the whole study population. Aortic elastic properties deteriorate and serum endocan level increases in patients with EH. Moreover, serum endocan level shows a correlation with deteriorated AEPs, and hence may a surrogate marker of escalating aortic stiffness in patients with newly diagnosed EH.
内皮功能障碍在原发性高血压（EH）和主动脉僵硬度的发生中起作用。我们通过超声心动图评估了血清内皮糖蛋白水平与用主动脉应变、主动脉扩张性和主动脉僵硬度指数评估的主动脉弹性特性（AEPs）之间的关系。新诊断的EH患者（n = 67）和对照组（n = 70）被纳入研究。EH组又被细分为1期和2期EH组。与对照组相比，EH组中发现内皮糖蛋白水平更高（分别为34.2±13.0 vs 24.1±7.3 ng/mL，P<0.001）。与对照组相比，EH组所有的AEP参数都更差。此外，在整个研究人群中，内皮糖蛋白水平与主动脉扩张性（r = -0.305，P<0.001）和主动脉应变（r = -0.181，P = 0.038）相关，但与主动脉僵硬度指数无关（r = 0.162，P = 0.064）。EH患者的主动脉弹性特性恶化且血清内皮糖蛋白水平升高。此外，血清内皮糖蛋白水平与恶化的AEPs相关，因此可能是新诊断的EH患者主动脉僵硬度升高的替代标志物。
