Department of Echocardiography, Nanjing Medical University, Changzhou, China.
Angiology. 2020 Jul;71(6):536-543. doi: 10.1177/0003319720911572. Epub 2020 Mar 13.
Both essential hypertension (EH) and type 2 diabetes mellitus (T2DM) can impair the elasticity of the ascending aorta. We prospectively enrolled 42 patients with T2DM, 44 patients with EH, 45 patients with T2DM and EH (T2DM + EH), and 41 healthy subjects (HS). They all underwent transthoracic echocardiography to measure ascending aorta inner diameters and a brachial blood pressure measurement to calculate aortic elastic parameters (ie, compliance, distensibility, strain, stiffness index, and Peterson elastic modulus). We found that there were no significant differences as regard with age, sex, body mass index, blood lipids and glucose, carotid atherosclerosis, and ascending aorta inner diameters among the 4 groups. The aortic elastic properties were significantly impaired in T2DM, EH, and T2DM + EH patients compared with the HS, and more impaired in EH and T2DM + EH patients than T2DM patients; there were no significant differences between EH and T2DM + EH patients. Our findings suggest that both T2DM and EH can impair aortic elastic properties. Essential hypertension may play a more important role in the process of ascending aorta sclerosis in patients with T2DM + EH.
原发性高血压（EH）和 2 型糖尿病（T2DM）均可损害升主动脉的弹性。我们前瞻性纳入了 42 例 T2DM 患者、44 例 EH 患者、45 例 T2DM 和 EH（T2DM+EH）患者和 41 例健康受试者（HS）。所有患者均接受经胸超声心动图检查以测量升主动脉内径，并进行肱动脉血压测量以计算主动脉弹性参数（即顺应性、扩张性、应变、僵硬度指数和 Peterson 弹性模量）。我们发现，4 组间的年龄、性别、体重指数、血脂和血糖、颈动脉粥样硬化和升主动脉内径无显著差异。与 HS 相比，T2DM、EH 和 T2DM+EH 患者的主动脉弹性特性明显受损，EH 和 T2DM+EH 患者的受损程度比 T2DM 患者更严重；EH 和 T2DM+EH 患者之间无显著差异。我们的研究结果表明，T2DM 和 EH 均可损害主动脉弹性特性。EH 在 T2DM+EH 患者升主动脉硬化过程中可能发挥更重要的作用。
