Meng Luyang, Wu Ziheng, Zhang Hongkun
Department of Vascular Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University,Hangzhou City, Zhejiang Province, 310009, China.
J Coll Physicians Surg Pak. 2019 Jan;29(1):90-92. doi: 10.29271/jcpsp.2019.01.90.
The aim of this study was to determine clinical efficacy of ulinastatin combined with octreotide in treatment of acute pancreatitis, and its effect on serum endothelin, endotoxin level and immune function. It was an analytical observational study carried out from September 2016 to March 2018. A total of 108 patients with acute pancreatitis were randomly divided into observation group and control group, 54 cases in each group. Control group was additionally treated with octreotide. Observation group was treated with ulinastatin. Therapeutic effects of two groups were compared. The total effective rate in observation group was higher than that in control group (p=0.046). After seven days of treatment, serum endothelin and endotoxin levels in observation group were lower than those in control group (both p<0.001); IgA, IgM and IgG levels in observation group were higher than those in control group (p=0.031, 0.007, and 0.001, respectively). Ulinastatin combined with octreotide can reduce level of endothelin and endotoxin and improve immune function.
本研究旨在探讨乌司他丁联合奥曲肽治疗急性胰腺炎的临床疗效及其对血清内皮素、内毒素水平和免疫功能的影响。本研究为分析性观察研究，于2016年9月至2018年3月开展。将108例急性胰腺炎患者随机分为观察组和对照组，每组54例。对照组加用奥曲肽治疗，观察组采用乌司他丁治疗，比较两组治疗效果。观察组总有效率高于对照组（p = 0.046）。治疗7天后，观察组血清内皮素和内毒素水平低于对照组（均p < 0.001）；观察组IgA、IgM和IgG水平高于对照组（分别为p = 0.031、0.007和0.001）。乌司他丁联合奥曲肽可降低内皮素和内毒素水平，改善免疫功能。
